What Is Iso Mitraphylline?
Iso mitraphylline is one of a huge variety of alkaloids that are found naturally in kratom. Alkaloids all have a physiological effect on the body when consumed. Some alkaloids, like mitragynine, provide stimulation and improved focus, while others, like 7-hydroxymitragynine, provide relaxation, sedation, and pain relief. Much less is known about iso mitraphylline than these other major alkaloids, but budding research suggests it has plenty of potential.
Iso mitraphylline is found naturally in a few different plants, one of which is the Mitragyna speciosa (kratom) tree. The specific purpose of iso mitraphylline and other alkaloids is unknown. Still, experts believe they play an essential role in protecting and propagating the kratom plant by affecting living things around it, including animals that might consume the plant or help pollinate it.
At this time, it’s unclear which — if any — kratom strains are highest in iso mitraphylline concentration. It is a minor alkaloid and appears only in small quantities in all strains. With more research, it might become evident which strains contain higher-than-average concentrations, but there are likely minimal differences between varieties at this time.
Little research is available thus far on the effects of iso mitraphylline. However, it has shown promise as an anti-cancer compound. Specifically, the alkaloid is known to induce phagocytosis, a cellular function by which cells consume and digest foreign and potentially harmful particles in the body.
Phagocytosis is one of the fundamental ways the body can combat the growth and proliferation of cancerous cells . In fact, phagocytosis of tumor cells is an emerging potential treatment for cancer and could be a way to prevent cancerous cells from developing in the body in the first place .
This, of course, does not yet suggest that kratom — and, more specifically, iso mitraphylline — can be used to cure cancer, but it does show promise in reducing the risk of cancer developing and spreading.
There could be additional benefits to consuming iso mitraphylline, but they have yet to be discovered. Further research could uncover other positive effects.
Kratom — Mitragyna speciosa — and cat’s claw — Uncaria tomentosa — are the two primary plants that have been proven to contain iso mitraphylline naturally. Both of these plants belong to the Rubiaceae family.
No. None of the alkaloids contained within kratom are opiates, and that includes iso mitraphylline. Some kratom alkaloids have effects similar to opiates, like an interaction with the opioid receptors in the body. However, iso mitraphylline does not share this trait, so it doesn’t even resemble opiates.
There’s minimal clinical research on using iso mitraphylline, so it’s unclear how safe the alkaloid is for acute or prolonged use. However, kratom is generally safe, as there are relatively few side effects and overall low severity of side effects. We’ll discuss the potential downsides below.
There are no specific side effects attributed to iso mitraphylline by itself, but some can come from kratom usage. The most severe side effect of consuming kratom is addiction. The herb can be habit-forming, so users should take care to take short breaks every week and longer, week-long breaks every month to prevent addiction.
Some additional, less severe side effects are listed below. Keep in mind that keeping doses low and taking tolerance breaks keeps the risk low.
- Gastrointestinal discomfort
- Lethargy (with prolonged use)
- Mental fog (with prolonged use)
Taking iso-mitraphylline by itself usually isn’t possible, and most users get the alkaloid directly from kratom, where it occurs naturally. As such, there are no recommended doses for iso mitraphylline, but below are some commonly suggested dosages for kratom.
- 1 to 3 grams of kratom powder for stimulative effects and increased concentration
- 3 to 6 grams for pain relief and relaxation
- 6 to 8 grams for severe pain relief, relaxation, sedation, and as a sleep aid
Again, since iso mitraphylline isn’t typically taken by itself and doesn’t have any noticeable effects that experts know of, it’s unclear how long the effects last. It’s usually more helpful to discuss how long the effects of kratom last, as this is how most users will be consuming iso mitraphylline.
Small doses of kratom — 3 grams or fewer — typically have effects lasting one to three hours. Larger amounts, up to 8 grams, can last as long as five hours.
Many alkaloids in kratom show promising benefits, but few have as much potential as iso mitraphylline to make a massive difference in modern medicine. This minor kratom alkaloid has anti-cancer properties and could help prevent and treat certain types of cancer.
Iso mitraphylline and other minor kratom alkaloids are typically only available via kratom powder. Most users take between 1 and 3 grams of powder to reap the potential benefits of iso mitraphylline. Additional benefits come with larger doses, including pain relief and relaxation, and can help with falling and staying asleep.
- Feng, M., Jiang, W., Kim, B., Zhang, C. C., Fu, Y. X., & Weissman, I. L. (2019). Phagocytosis checkpoints as new targets for cancer immunotherapy. Nature Reviews Cancer, 19(10), 568-586.
- Lecoultre, M., Dutoit, V., & Walker, P. R. (2020). Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: a review. Journal for Immunotherapy of Cancer, 8(2).