Drug Interactions, Kratom Guides

Kratom & Doxycycline: Is This A Safe Combination?

Doxycycline is a tetracycline antibiotic that fights bacteria. It comes from a compound called oxytetracycline.

Doxycycline treats gram-positive and gram-negative bacteria and aerobes, anaerobes, and other bacteria. It helps various conditions such as sexually transmitted diseases, respiratory tract infections, acne vulgaris, and malaria.

There are very few chances of any major interaction between doxycycline and kratom, a substance derived from the plant Mitragyna speciosa. However, consuming them together could decrease their bioavailability, making them less effective and potentially more dangerous. 

Last updated 3 months ago by Dr. Devin Carlson

Kratom & Doxycycline: Is This A Safe Combination?

Does Kratom Interact With Doxycycline (Vibramycin)?

Consuming kratom with doxycycline can interact in two possible ways. This can have moderate risks. Kratom could bind to doxycycline, causing it to be ineffective. They can also act as metabolic competitors and cause the metabolization of one or both to be delayed. This interaction can cause an increased risk of side effects.

It is always better to get proper consultation from your prescribing physician before taking kratom and doxycycline together.

Kratom Can Decrease Doxycycline (Vibramycin)’s Effects (Antagonistic Interaction)

Kratom and doxycycline can interact antagonistically. Doxycycline is best taken alone, if tolerated, for best absorption. Liquids and food can make it less effective. Talk with your doctor, and make sure there are at least two hours between the kratom dose and the doxycycline to be safe.

Kratom & Doxycycline Can Have Slowed Elimination (Metabolic Inhibition)

There is a possible chance of metabolic interaction between kratom and doxycycline.

Kratom is metabolized by the cytochrome enzymes of the liver, namely CYP3A4, CYP2D6, and CYP2C9.

But while doxycycline does not use the CYP enzymes for metabolism, it can have an inhibitory effect on CYP3A [1].

Because of this, consuming doxycycline and kratom together can slow the metabolization and elimination of both, allowing them to stay in the body for longer and create additional adverse effects.

Kratom & Doxycycline (Vibramycin) Interactions

Doxycycline is a tetracycline antibiotic that helps the body fight bacteria.

Tetracycline treats bacterial infections such as those of the skin, intestines, respiratory tract, eye infections, urinary tract, genitals, lymph nodes, and other body systems.

There are a few other tetracyclines, all of which will share a similar level of risk when used alongside kratom.

Other tetracyclines that kratom will interact with include:

  • Chlortetracycline
  • Oxytetracycline
  • Demeclocycline
  • Methacycline
  • Minocycline
  • Tigecycline

Is it Safe to Take Kratom With Doxycycline (Vibramycin)?

Consuming kratom with doxycycline can cause moderate reactions. Kratom’s inhibitory effects on the CYP enzymes decrease doxycycline’s bioavailability if both are taken simultaneously.

Make sure there’s at least a 2-hour time interval between the consumption of these medications.

However, do not take these medications without first consulting your physician. If you experience any odd side effects, get medical aid immediately.

What is Doxycycline (Vibramycin)?

Doxycycline is a tetracycline antibiotic that treats bacterial infections. It’s made from oxytetracycline synthetically. This medication is a second-generation tetracycline, making it less harmful than first-generation tetracyclines.

Doxycycline treats infections caused by gram-positive and gram-negative bacteria, aerobes and anaerobes, and other bacteria. Due to antibiotic resistance, doxycycline is not for staphylococcal infections.

Doxycycline is bacteriostatic, meaning it inhibits protein production and has antibacterial properties. Bacteriostatic antibiotics prevent germs from growing or keeping them in a stationary state.

By attaching to the 30S ribosomal subunit, which is only in bacteria, doxycycline prevents the creation of bacterial proteins. This action stops transfer RNA from binding to messenger RNA at the ribosomal subunit, preventing the addition of amino acids to polypeptide chains and the production of new proteins. This halts bacterial growth and allows the immune system to destroy and eliminate the infection.

Doxycycline (Vibramycin) Details & Specifications:

Drug NameDoxycycline
Trade nameActiclate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin
CYP MetabolismNon
Interaction With KratomIndirect metabolic competitors
  Risk of InteractionModerate

What is Doxycycline (Vibramycin) Used For?

Doxycycline has a variety of indications. Some of them are:

For Treatment of Sexually Transmitted Diseases

Doxycycline is used to treat uncomplicated urethral infections, endocervical or rectal infections, and lymphogranuloma venereum caused by Chlamydia trachomatis. It works by entering the cell body of the bacteria and blocking the production of the proteins required by the bacteria for survival and reproduction.

It treats nongonococcal urethritis caused by Ureaplasma urealyticum, granuloma inguinale caused by Klebsiella granulomatis, uncomplicated gonorrhea caused by Neisseria gonorrhoeae, chancroid caused by Haemophilus ducreyi.

Doxycycline’s physicochemical properties (liposolubility) enable rapid diffusion in tissues and organs. It has a high bioavailability and a long elimination half-life, allowing for one or two daily dosages to be taken orally. Doxycycline is mostly used for sexually transmitted diseases due to its efficacy, good tolerability, and easy oral administration [2].

In the Treatment of Respiratory Infections

It can be used to treat respiratory tract infections caused by organisms such as Haemophilus influenza, Klebsiella species, Streptococcus pneumonia, etc. It is also important in the empirical treatment of hospitalized patients with mild to moderately severe community-acquired pneumonia. It is especially useful for treating acute bronchitis and acute exacerbations of chronic bronchitis [3].

Treatment of Acne

Doxycycline helps treat acne vulgaris [4]. Unlike other infectious conditions, the doxycycline treatment for acne encompasses a long-term dosage that may extend for several weeks. It is effective and safe for use in acne treatment and has long-term and highly beneficial effects in treating this condition.

Malaria Treatment

Doxycycline is also indicated for malaria treatment [5]. It is indicated for the prevention of malaria due to Plasmodium falciparum in short-term travelers (<4 months). This is mainly for those areas with chloroquine or pyrimethamine-sulfadoxine-resistant strains.

What’s the Dose of Doxycycline (Vibramycin)?

The recommended dose of doxycycline is 200 mg orally per day in two divided doses. The dosage changes according to the need. 

Generic & Brand Name Versions

  • Acticlate
  • Adoxa
  • Apprilon
  • Atridox
  • Doryx
  • Doxy
  • Doxycin
  • Lymepak
  • Mondoxyne
  • Monodox
  • Morgidox
  • Okebo
  • Oracea
  • Periostat
  • Targadox

What Are the Side Effects of Doxycycline (Vibramycin)

  • Anorexia
  • Dental discoloration
  • Diarrhea
  • Drug rash with eosinophilia and systemic symptoms
  • Dysphagia
  • Enterocolitis
  • Erythema multiforme
  • Esophageal ulcer
  • Esophagitis
  • Exacerbation of systemic lupus erythematosus
  • Exfoliative dermatitis
  • Glossitis
  • Headache
  • Hemolytic anemia
  • Hepatotoxicity
  • Hypoglycemia
  • Inflammatory anogenital lesion
  • Intracranial hypertension
  • Nausea
  • Neutropenia
  • Pericarditis
  • Serum sickness
  • Skin hyperpigmentation
  • Thrombocytopenia
  • Toxic epidermal necrolysis
  • Upper abdominal pain
  • Urticaria
  • Vomiting

What is Kratom?

Kratom is from the leaves of an evergreen tree (Mitragyna speciosa) and is most commonly found in Southeast Asia.

Kratom acts on opioid receptors, and other systems, causing some people to assume it’s dangerous. However, that’s not the case. As with most things, use it wisely, and there won’t be any issues. It’s important to note that kratom carries minimal risk even with misuse. It’s almost impossible to overdose on, and any addiction to it is far easier to avoid and overcome than with things like opioids. The biggest danger comes from using it with other substances. Kratom interacts with many medications, so always ensure there won’t be an issue before combining them.

Kratom acts as a stimulant in small doses, making users feel more energized. As the dosage increases, it reduces pain and acts as a sedative.

We’ll go into its uses and side effects below.

Related: Is Kratom Dangerous?

What’s Kratom Used For?

Kratom is similar to opioids in many ways, but it also affects the adrenergic, dopamine, and serotonin systems, making it useful for many things.

It’s native to Southeast Asia, and the people there have been using it as medicine for centuries. The West has finally caught on to how great it is — here are the most common uses. 

What is the Dose of Kratom?

The best rule of thumb is to start low and keep usage to a minimum. The dose changes the effects, so it’s essential to understand how kratom works.

  • Energy, focus, creativity, and euphoria come in lower doses — 2-5 g.
  • Relaxation, pain relief, a calm mind, and eventually sedation come with larger doses — 6-12 g.

Anything over 8 g is a heavy dose and should be avoided unless you have experience with kratom.

Suggested Reading: How Much Kratom Should I Take?

What Are the Side Effects of Kratom?

Kratom’s side effects are usually short-term and fade pretty quickly. They tend to happen when you take too much — another reason to keep dosage low.

Here are the common side effects to watch out for:

More severe but rarer side effects include:

To avoid addiction, take breaks now and then from kratom, only use it when necessary, and stick with the smallest amount possible.

What Are the Different Types of Kratom?

As we mentioned, dose plays a considerable role in the effects you’ll feel. Now, we’ll discuss the other factor — strains.

Kratom strains come about due to the harvesting process. Early harvest, allowing the leaves to mature and fermenting them all play a role in the alkaloid levels, changing the effects.

While all kratom is energizing in smaller amounts and sedating in larger ones, each strain specializes in an area and is better for achieving specific effects.

Here’s what you can expect from each strain.

A) White Vein Kratom

White-veined strains are harvested before they reach full maturity. They can help with improved energy, cognitive performance, mental attention, vitality, and mildly pleasant feelings — effects similar to caffeine.

B) Red Vein Kratom

A kratom leaf must be fully ripe before it may produce red veins. Red-veined kratom has the most 7-hydroxymitragynine, the alkaloid most responsible for pain relief.

These strains are very effective analgesics and sedatives. Because of their calming abilities, many people use them to help manage anxiety.

C) Green Vein Kratom

Medium-mature leaves make green vein kratom. When the leaves are selected, the alkaloid levels are at their peak. Because of this, these strains fall in the middle as far as their effects go. They can provide a little of everything but excel at nothing. Green strains are perfect for beginners or for those that don’t require a potent white or red.

E) Yellow Vein Kratom

Yellow vein kratom is a form of green vein kratom whose color and effects cahnge throughout the drying process. Another theory is that yellow strains are fermented whites.

These strains increase feelings of pleasure and vigor while lowering anxiety and depression. They are similar to green because the effects are mild and balanced, providing pain relief, enhanced concentration, and a better overall mood for a surprising amount of time.

Key Takeaways: Is it Safe to Mix Kratom & Doxycycline (Vibramycin)?

There can be mild to moderate side effects resulting from mixing kratom and doxycycline. A slowdown in their metabolism and a decreased bioavailability of kratom can result from mixing them, making one or both ineffective.

Don’t start taking these meds on your own, and always consult your prescribing physician first. If you have to take them anyways, make sure there is a 2-hour time interval between them.


  1. Wang, X., Yang, Y., Martínez, M. A., Martínez, M., Lopez-Torres, B., Martínez-Larrañaga, M. R., … & Ares, I. (2021). Interaction Between Florfenicol and Doxycycline Involving Cytochrome P450 3A in Goats (Capra hricus). Frontiers in Veterinary Science, 1218.
  2. Peyriere, H., Makinson, A., Marchandin, H., & Reynes, J. (2018). Doxycycline in the management of sexually transmitted infections. Journal of Antimicrobial Chemotherapy, 73(3), 553-563.
  3. Pestel, M. (1975). Doxycycline in the treatment of respiratory tract infections. Chemotherapy, 21(Suppl. 1), 91-108.
  4. Del Rosso, J. Q. (2015). Oral doxycycline in the management of acne vulgaris: current perspectives on clinical use and recent findings with a new double-scored small tablet formulation. The Journal of clinical and aesthetic dermatology, 8(5), 19.
  5. Tan, K. R., Magill, A. J., Parise, M. E., & Arguin, P. M. (2011). Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis. The American journal of tropical medicine and hygiene, 84(4), 517.

Learn More About Kratom-Drug Interactions