Does Kratom Interact With Vardenafil (Levitra)?
Yes, kratom interacts with PDE5 inhibitors like vardenafil, though this will not necessarily cause severe adverse effects. You need to talk to your doctor to determine the risks of this combination in your case.
Most pharmacy drugs are metabolized in the liver by a group of enzymes known as the cytochrome P450 (CYP450). Vardenafil and other PDE5 inhibitors are metabolized by the CYP3A4 enzyme [1, 2].
Similarly, kratom also requires the CYP3A4 and the CYP2D6 enzyme for its proper breakdown .
If kratom and vardenafil are taken together, they will compete for their metabolism in the liver. This could lead to a drug build-up, which increases the incidence of side effects.
This pharmacological phenomenon is known as metabolic inhibition.
Is it Safe to Take Kratom With Vardenafil?
The metabolic interaction between kratom and vardenafil does pose a moderate risk. Since kratom slows down vardenafil’s metabolism, the side effects might be worse.
What is Vardenafil (Levitra)?
Vardenafil is a prescription medication used to treat erectile dysfunction (ED).
Vardenafil is a PDE5 inhibitor; this is a class of compounds that work by blocking the action of the PDE5 enzyme and thus increasing blood flow to the penis and other tissues.
In general, the pharmacological profile of vardenafil is much the same as that of other PDE5 inhibitors like tadalafil (Cialis) and mirodenafil (Mvix). However, there are still differences between all of them.
For instance, vardenafil is more potent and selective than sildenafil at inhibiting PDE5. The side effects also vary between drugs . Fatty foods affect the pharmacokinetic functioning of vardenafil but not that of tadalafil .
|Trade Name||Levitra, Staxyn, Vivanza|
|Interaction With Kratom||Metabolic inhibitor|
|Risk of Interaction||Moderate|
What is Vardenafil Used for?
According to the FDA, vardenafil — like other PDE5 inhibitors in its class — can treat erectile dysfunction.
Studies suggest there are minimal differences between PDE5 inhibitors in terms of efficacy. Vardenafil is usually just as effective and well-tolerated as other PDE5 inhibitors .
Research also suggests that vardenafil may effectively treat premature ejaculation .
What’s the Dose of Vardenafil?
Vardenafil is available in 2.5, 5, 10, and 20 mg tablets; it’s usually prescribed in a single 10 mg dose and is taken one hour before sexual activity . The dosage usually does not exceed 20 mg. For adults over 65, one 5 mg dose is the recommended amount.
In any case, you shouldn’t take more than one pill a day.
Generic & Brand Name Versions
Vardenafil is sold under the following brand names:
What Are the Side Effects of Vardenafil?
The FDA has identified that the use of vardenafil may cause the following side effects:
- Abdominal pain
- Back pain
- Elevated risk of severe cardiovascular events
- Risk of priapism
- Sudden loss of hearing
- Sudden loss of vision
Contraindications to taking vardenafil include:
- Administration with nitrates and nitric oxide donors
- Hepatic impairment
- Medications that affect the QT interval
- Renal impairment
What is Kratom?
If you don’t know what kratom is, you owe it to yourself to find out. Chances are, it could benefit you in some way.
It doesn’t make you high, and its safety profile is impressive, though we’ll get to its side effects later.
Kratom (Mitragyna speciosa) grows in Thailand, Vietnam, Indonesia and other countries in Southeast Asia. Though they have different names for it, the people there have been chewing its leaves for a long time as a means to combat fatigue and pain.
What makes kratom unique? It contains many alkaloids, but two stand out: mitragynine and 7-hydroxymitragynine. These provide it with most of its essential benefits.
The rest of the world is just starting to utilize it, but many governments are skeptical. Kratom’s opioid-like effects scare some people, and some states have banned it. The truth is that, when used correctly, kratom is much safer than prescription opioids. That’s why it’s crucial to know your state’s laws and be involved so kratom can remain legal.
Suggested Reading: Is Kratom Dangerous?
What is Kratom Used for?
Kratom is not some miracle plant that makes everything better, but it does offer an array of pharmacological effects.
In lower doses, it acts as a stimulant. It’s used as an alternative to coffee for fueling late-night study sessions or long days at work.
In higher doses, it acts more like an opiate. Like other opiates, kratom is often used to manage pain, anxiety, insomnia, and mood disorders.
Here’s a quick look at a few modern reasons for using kratom:
- ADHD (Attention Deficit & Hyperactivity Disorder)
- Arthritis pain
- Benzodiazepine withdrawal syndrome
- Chemotherapy-related pain
- Chronic back pain
- Energy & focus
- Opiate withdrawal symptoms
- Nerve pain
- Psoriatic arthritis
- Weight loss
What’s the Dose of Kratom?
When considering how much kratom to take, you should always keep a few things in mind.
Formulaic amounts are never to be trusted entirely. These don’t consider things like body weight, method of consumption, tolerance, needs, etc.
There are general suggestions, but you should always start with a low dose and work yourself up until you know how it’ll affect you.
To get you started, here’s the standard kratom dosage guide:
- Low dose (1 – 5 g)
- Medium dose (5 – 10 g)
- High dose (10 – 15 g)
For more detailed information, check out our dose calculator and guide.
What Are the Side Effects of Kratom?
As we mentioned, there are some side effects associated with kratom. These are minor and usually noticed when taking more significant amounts. However, if you use kratom long-term, and in higher doses, you might experience more severe side effects.
These are the most common side effects: of kratom
- Anxiety or restlessness
- Frequent urination
- Heart palpitations
- Nausea and vomiting
- Sedation and prolonged sleepiness
- The Wobbles
More serious side effects include:
- Addiction & dependence
- High blood pressure
- Liver damage (with long-term use)
- Low libido
- Poor appetite
- Withdrawal symptoms
Although kratom use can become addictive, it rarely causes an overdose.
What Are the Different Types of Kratom?
To get the most out of your kratom, you should learn about the main kratom strains.
If you learn to use the straight strain for the job and the proper dosage: you’ll always be in complete control of your kratom experience.
White Vein Kratom
White-veined kratom strains tend to cause euphoria and increased concentration. These strains might do more harm than good if you deal with anxiety. But if you need energy and that cup of coffee isn’t cutting it, white strains can help. Same if you’re studying and need to focus or feel like your creativity is lacking.
Red Vein Kratom
As opposed to white, red vein kratom is all about the pharmacological properties of the kratom plant.
It’s very popular with those who want to replace their antidepressant or painkillers prescriptions with a safer herbal option. Just be careful — these also make you tired. Check each strain and find one more energizing if you need to stay awake.
Green Vein Kratom
If white and red are at separate ends of the kratom spectrum, green vein kratom is right in the middle.
These strains excel at producing an equal measure of all the benefits kratom offers. You won’t find extreme results, but sometimes that’s not what you’re after.
Yellow Vein Kratom
Yellow vein strains are quite similar to green — nothing remarkably, just reliable and lowkey. These appear to be the mildest out of all the strains.
Key Takeaways: Is it Safe to Mix Kratom & Vardenafil (Levitra)?
It should never be considered completely “safe” to combine compounds that already carry a certain level of risk alone — as kratom and vardenafil do.
However, if both these drugs are taken responsibly and no contraindication is present, the risk is low to moderate. Since there are too many factors, it’s best to ask your doctor to ensure you’re clear about using both. That simple step can save a lot of headaches (or worse).
- Levitra (vardenafil hcl) – Food and Drug Administration. (n.d.). Retrieved January 11, 2023, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021400s011lbl.pdf
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- Park, H. J., Moon, K. H., Lee, S. W., Lee, W. K., Kam, S. C., Lee, J. H., & Park, N. C. (2014). Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. The World Journal of men’s health, 32(1), 18-27.
- Nagao, K., Ishii, N., Kamidono, S., Osada, T., & Vardenafil (Levitra) Clinical Trial Group. (2004). Safety and efficacy of vardenafil in patients with erectile dysfunction: result of a bridging study in Japan. International journal of urology, 11(7), 515-524.
- Aversa, A., Pili, M., Francomano, D., Bruzziches, R., Spera, E., La Pera, G., & Spera, G. (2009). Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. International Journal of Impotence Research, 21(4), 221-227.
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Vardenafil. [Updated 2017 Aug 2]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548920/