Drug Interactions

Interactions Between Kratom & Magic Mushrooms

Kratom is a herbal supplement many people use to battle lethargy, chronic pain, anxiety, and even deal with opiate withdrawal symptoms. Along with various psychedelics — magic mushrooms included — it is becoming increasingly popular worldwide.

This article will show you the risks of taking kratom and magic mushrooms together, how they interact with one another, and what they’re typically used for. We’ll also cover their side effects and things you should keep in mind before trying this combination.

Last updated 1 month ago by Dr. Devin Carlson

Interactions Between Kratom & Magic Mushrooms

Does Kratom Interact With Magic Mushrooms?

Kratom and magic mushrooms can interact, though the result of such interaction varies from person to person. For this reason, we recommend discussing the topic with your doctor before using them together.

Studies suggest that mitragynine — one of kratom’s main alkaloids — acts as an antagonist to serotonin 5-HT2A receptors, displaying potential as an antipsychotic [1].

On the other hand, Psilocybe cubensis, for example, binds to the same receptors to achieve its psychoactive effects.

Although studies on their interaction are still needed, this suggests that kratom may counteract the hallucinogenic effects of magic mushrooms. As a result, their combination could be impractical, depending on the purpose of their use.

The interaction between kratom and magic mushrooms may fall into the following categories.

Decreased Hallucinogenic Effect (Agonistic Interaction)

Magic mushrooms activate serotonin receptors in our brain to produce euphoria and visual alterations, among many other effects. Kratom alkaloid mitragynine is an antagonist to these receptors and can interfere in the process [2].

The expected interaction is decreased psilocybin’s effects, especially its hallucinogenic qualities.

Still, many users have reported not experiencing such results, and others claim that kratom provided them with a more pleasant experience while using psychedelics.

Slowed Elimination (Metabolic Competition)

Every drug is metabolized in the liver by specific enzymes. When one of these enzymes tries to work on two substances simultaneously, the process becomes much slower. This means they are stuck in our system for longer, increasing the risk of side effects.

Kratom and magic mushrooms are metabolized by enzymes CYP2D6, CYP2C9 and CYP3A4, resulting in a metabolic competition [3, 4]. You can deal with this by using lower doses of each product or with less frequency.

Kratom & Psychedelics’ Interactions

Psilocybin, or magic mushrooms, are classified as psychedelics, a class of psychoactive substances capable of producing changes in mood, cognitive processes, and perception.

Most psychedelics are likely to share similar interactions with kratom as magic mushrooms.

Other psychedelics that can interact with kratom are:

Is It Safe to Take Kratom With Magic Mushrooms?

It is generally safe to take kratom and magic mushrooms simultaneously, the greater risk being a reduced intensity of the experience. No further downsides are probable, but to be sure, you can always reduce your doses or use only one drug at a time.

We recommend avoiding it if you are inexperienced. If you’re taking any medication, you should always consult your doctor before taking any of these.

What Are Magic Mushrooms?

Magic mushrooms are an informal group of fungi containing psilocybin and psilocin, naturally occurring psychedelic compounds. They grow all over the world, except in frigid regions. You’ll likely find them in the wild on dung and fertile soil.

Recent studies suggest they have incredible therapeutic potential, with a very low potential for abuse. Their accessibility has made them popular for recreational use, but they remain illegal in most countries.

Magic mushrooms’ main psychoactive compounds interact with serotonin receptors in our brains, causing a unique brain function that changes how we perceive our senses and the world around us.

Magic Mushrooms Details & Specifications

Drug NamePsilocin, Psilocybin
Trade NamePsilocin, Psilocybin
CYP MetabolismCytochrome P450
Interaction With KratomMetabolic competitor
Risk of InteractionLow

What Are Magic Mushrooms Used For?

The primary use of magic mushrooms was recreational until researchers began studying their effects on patients with mental illness. Today, studies are being conducted to test psilocybin’s effectiveness in improving psychiatric disorders and general wellness [5, 6].

Psilocybin can help treat:

  • Major Depressive Disorder
  • Anxiety Disorders
  • End-of-Life Mood Disorders
  • Post-Traumatic Stress Disorder (PTSD)
  • Migraines and Cluster Headaches
  • Addiction

Thanks to its capability to assist spiritual and philosophical breakthroughs, psilocybin-assisted therapy is used to handle treatment-resistant disorders. In addition, it can improve one’s outlook on life and promote a better understanding of oneself.

What’s the Dose of Magic Mushrooms?

The dose of psychedelic mushrooms will depend on your body weight and desired effects. It is best to carefully measure each amount since it can be easy to go overboard unintentionally, potentially provoking side effects.

In the case of, for example, Psilocybe cubensis, typical doses are the following:

  • Microdose: 0.1 to 0.5 grams
  • Low dose: 0.5 to 1.75 grams
  • Medium dose: 1.75 to 3.5 grams
  • High dose: 3.5 to 5 grams
  • “Heroic dose:” 5 grams and above

The best way to start with psilocybin mushrooms is with low doses, moving on gradually to more significant amounts as you see fit. High doses are not recommended unless experienced and entirely comfortable with the environment, and heroic doses are heavily discouraged.

Other Names for Magic Mushrooms & Common Species

Magic mushrooms are called differently depending on the culture or region. There are also numerous species of psilocybin-containing mushrooms worldwide. We’ll cover these below.

Other names for psilocybin mushrooms include:

  • Shrooms
  • Psychedelic mushrooms
  • Psilocybin mushrooms
  • Sacred mushrooms

Other common magic mushroom species include:

  • Psilocybe cubensis
  • Psilocybe azurescens
  • Psilocybe semilanceata
  • Panaeolus cyanescens
  • Gymnopilus junonius
  • Inocybe aeruginascens

What Are the Side Effects of Magic Mushrooms?

Magic mushrooms can present side effects when the user is not in the right mindset, or the dose is too large. We commonly refer to this as a “bad trip.” Remember that these side effects can last a couple of hours.

The most common side effects are:

  • Nausea
  • Loss of appetite
  • Sweating
  • Headaches
  • High blood pressure
  • Paranoia
  • Confusion

What Is Kratom?

Kratom is a herbal extract that can be used as powder or tea. It comes from the leaves of a tree that grows naturally in Southeast Asia, where natives have traditionally used it as medicine and to push through work for centuries.

What’s Kratom Used For?

Many people use kratom to improve their lifestyles, deal with medical conditions, or simply for recreational purposes. The effects of the herb largely depend on the strain and the dose, so try different options to achieve the desired results.

Kratom is used for:

What’s the Dose of Kratom?

The dose of kratom is determined by the user’s weight and the effect they plan to achieve. Generally, larger amounts provide analgesic effects, while smaller doses ensure an energy boost.

The usual recommended kratom dosage is:

  • 0.025 grams/pound for stimulation
  • 0.04 grams/pound for pain relief

It is always best to start with lower doses until you find one that adjusts to your body and goals. Taking too much kratom typically results in undesired side effects.

What Are the Side Effects of Kratom?

Although kratom is considered safe, it can present side effects. These are usually caused by misuse and can be avoided by lowering the dose and taking kratom less often.

Side effects of kratom include:

Cases of severe misuse can lead to more serious side effects such as addiction, jaundice, arrhythmia, hypogonadism, and acute kidney or liver damage. This is, however, extremely uncommon and can be avoided with moderate use.

What Are the Different Types of Kratom?

We classify the different varieties of kratom according to their alkaloid composition, represented by the color of the leaf veins. In this section, we’ll go over their various properties.

White Vein Kratom

White vein kratom offers the most substantial energetic and euphoric benefits, and it helps clear the mind and increase productivity. It is an excellent alternative to coffee since it provides stimulation without the risk of caffeine-induced anxiety.

Red Vein Kratom

Red vein kratom is different from white vein strains in providing pain and anxiety relief instead of stimulation. Its potent sedative quality makes it perfect for those battling insomnia and chronic pain.

Green Vein Kratom

Green vein kratom balances the typical stimulation of white-veined kratom and sedation of red-veined kratom without being overwhelming. Since it is the most balanced strain, it is the best choice for beginners seeking a complete kratom experience.

Yellow Vein Kratom

Yellow vein kratom is a balanced yet potent alternative favored by many for its nootropic benefits. It is excellent for improving mood and concentration and relieving pain and anxiety.

Key Takeaways: Interactions Between Kratom & Magic Mushrooms

Kratom and psilocybe cubensis are both safe to take on their own. With responsible use, they can offer great psychological benefits to their users.

Although no studies detail their interaction, evidence suggests that their effects may cancel each other out. Kratom can act as an antipsychotic and reduce the intensity of psilocybin.

Furthermore, there is a risk of slower metabolization in the liver since both drugs compete for the same enzymes. This means that the substances will remain in the system for longer, which may cause undesired side effects.


  1. Johnson, L. E., Balyan, L., Magdalany, A., Saeed, F., Salinas, R., Wallace, S., Veltri, C. A., Swogger, M. T., Walsh, Z., & Grundmann, O. (2020). The Potential for Kratom as an Antidepressant and Antipsychotic. The Yale journal of biology and medicine, 93(2), 283–289.
  2. Halberstadt, A. L., Nichols, D. E. (2010). Serotonin and Serotonin Receptors in Hallucinogen Action. Handbook of Behavioral Neuroscience, 21, 621-636.
  3. Kamble, S. H., Sharma, A., King, T. I., León, F., McCurdy, C. R., & Avery, B. A. (2019). Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica; the fate of foreign compounds in biological systems, 49(11), 1279–1288.
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  5. Thomas, K., Malcolm, B., & Lastra, D. (2017). Psilocybin-assisted therapy: A review of a novel treatment for psychiatric disorders. Journal of Psychoactive Drugs, 49(5), 446-455.
  6. Ross, S., Bossis, A., Guss, J., Agin-Liebes, G., Malone, T., Cohen, B., … & Schmidt, B. L. (2016). Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial. Journal of psychopharmacology, 30(12), 1165-1180.