Drug Interactions, Kratom Guides

Can You Take Vicodin & Kratom Together?

Kratom (Mitragyna speciosa) and Vicodin should NEVER be taken together. 

Both of these substances interact with the opioid receptors, making them a very bad mix. Additionally, Vicodin on its own has a lot of potential side effects, death being the most serious. 

If you must take Vicodin, tell your doctor about every other substance you’re taking. This is for your safety.   

Last updated 7 months ago by Dr. Devin Carlson

Can You Take Vicodin & Kratom Together?

Does Kratom Interact With Vicodin?

Vicodin, which is a combination of hydrocodone and acetaminophen, is a dangerous drug on its own. The root form, hydrocodone, is known as Oxycontin. 

Mixing just hydrocodone and kratom can cause liver damage. Also, adding hydrocodone as an adulterant to kratom has been known to cause people to overdose or even die.

Because hydrocodone is an opioid [1], there is always the risk of a negative reaction with kratom. This agonistic interaction happens because kratom and Vicodin interact with the opioid receptors. Due to their similar effects, mixing them could lead to side effects or an overdose.    

Vicodin is metabolized by CYP2D6 [2], and so is kratom [3] —this puts them in a bad position to be used together. Taking Vicodin and kratom daily will cause them to build up in your system and could lead to toxicity. 

Because a sedative may make it even worse, you’ll want to avoid taking a red strain of kratom.  

Kratom & Opioid Interactions

Vicodin is classified as an opioid and a narcotic, both of which come with a high risk for dependence and addiction. Vicodin works by binding and activating the opioid receptors in the central nervous system. 

There are dozens of other opioid medications, all of which will share a similar level of risk when used alongside kratom. Kratom should never be used in combination with opioid medications unless otherwise specified by your prescribing doctor.    

Other related opioids kratom will interact with include:

  • Buprenorphine (Cizdol & Brixadi)
  • Codeine
  • Pethidine (Meperidine & Demerol)
  • Fentanyl (Abstral & Actiq)
  • Hydrocodone (Hysingla ER, Zohydro ER & Hycodan)
  • Hydromorphone (Dilaudid)
  • Methadone (Methadose & Dolophine)
  • Morphine (Kadian & Roxanol)
  • Oxycodone (Percodan, Endodan, Roxiprin, Percocet, Endocet, Roxicet & OxyContin)
  • Tramadol (Ultram, Ryzolt & ConZip)

Is it Safe to Take Kratom With Vicodin?

No, it is not safe to take kratom with Vicodin. 

In general, it’s never safe to take any opioid with kratom. Although kratom can provide relief to people who are battling opioid withdrawal, it should not be taken with an opioid.

19.7% of people who have died of a kratom overdose were also taking an opioid such as Vicodin.

If you are still wondering whether you can get away with it, be sure to ask your doctor.  

What is Vicodin?

Vicodin is a prescribed medication for severe pain. 

Once you take it, it will change how your body responds to pain. The acetaminophen in Vicodin can also reduce fever. 

This medication is often taken by people who have severe pain that won’t be reduced by taking other medications. It’s commonly used for cancer patients, among others. 

Vicodin can provide enough pain relief for people to work. However, if you discontinue it quickly, it can cause a lot of withdrawal symptoms.   

Vicodin Details & Specifications:

Drug NameHydrocodone/acetaminophen
Trade Name Vicodin 
Other Names (other generics)Norco, Lortab, Hycet, Zolvit, Zydone, Lorcet, Maxidone, Co-gesic, Liquicet, Xodol, Stagesic, Zamicet
CYP Metabolism CYP2D6
Interaction with KratomAgonistic Interaction 
Risk of Interaction High

What is Vicodin Used For?

Vicodin is generally prescribed for severe pain. 

What’s the Dose of Vicodin?

A basic dose of Vicodin contains 5 mg of hydrocodone and 300 mg of acetaminophen. Adults should take one to two tablets at a time every four to six hours. They shouldn’t exceed eight tablets per day. 

The step-up dose contains 7.5 mg of hydrocodone and 300 mg of acetaminophen. Adults should take one tablet at a time every four to six hours. They shouldn’t exceed six tablets per day. 

The highest dose contains 10 mg of hydrocodone and 300 mg of acetaminophen. Adults should take one tablet at a time every four to six hours. They shouldn’t exceed six tablets per day. 

Generic & Brand Name Versions of Vicodin

Vicodin contains hydrocodone (Oxycontin) and acetaminophen (Tylenol). It is available in many forms, including: 

  • Norco
  • Lortab
  • Hycet
  • Zolvit
  • Zydone
  • Lorcet
  • Maxidone
  • Co-gesic
  • Liquicet
  • Xodol
  • Stagesic
  • Zamicet

What Are the Side Effects of Vicodin?

Vicodin has many potential side effects. It may be necessary to take a laxative when taking Vicodin. Ask your doctor for a laxative recommendation. 

  • Nausea 
  • Vomiting 
  • Constipation 
  • Lightheadedness 
  • Dizziness
  • Drowsiness 
  • Sleep apnea 
  • Mental/mood changes 
  • Stomach/abdominal pain
  • Difficulty urinating 
  • Unusual tiredness 
  • Weight loss 
  • Slow/shallow breathing 
  • Seizure 
  • Fainting 
  • Difficulty waking up 
  • Itching/swelling
  • Rash
  • Trouble breathing 
  • Severe dizziness 

What is Kratom?

Kratom is a plain-looking evergreen tree originating from Southeast Asia. In lower doses, it acts as a sedative. In higher doses, it provides pain relief. 

What’s Kratom Used For?

If you’re in Southeast Asia, the odds are high that you chew kratom leaves. However, you can also use it as a powder, brew it into a tea, or even smoke it

Kratom is used to treat a variety of conditions, ranging from enhancing physical performance to anxiety. 

What’s The Dose of Kratom?

The ideal dosage of kratom varies per person. 

Generally speaking; however, the kratom dosage guidelines are: 

  • Low-Dose Kratom (2 to 6 grams) 
  • High-Dose Kratom (6 to 12 grams)

Stick to 12 grams or less, or you may experience the side effects of kratom

What are the Side Effects of Kratom?

  • Nausea 
  • Insomnia
  • Hyperpigmentation 
  • Dizziness
  • Poor appetite 
  • Low libido 
  • Tremors or muscle contractions 
  • Dizziness 
  • Itchy skin
  • Low blood pressure 
  • Seizures 

What are the Different Types of Kratom?

  1. White Vein Kratom — A stimulating strain that boosts mood and motivation. 
  2. Red Vein Kratom — This relaxing and sedating strain helps with pain relief and sleep. 
  3. Green Vein Kratom — A balanced strain that’s stimulating and used for anti-anxiety. 
  4. Yellow Vein Kratom — Weaker than the white vein, improves concentration and enhances mood.

Key Takeaways: Is it Safe to Mix Kratom & Vicodin?

It is NOT safe to take Vicodin and kratom together. 

Almost 20 percent of accidental overdose deaths included kratom mixed with a prescription opioid. Vicodin also has a very high risk of addiction. 

You should speak to your doctor if you’re still considering mixing Vicodin and kratom. 


  1. Marco, C. A., Plewa, M. C., Buderer, N., Black, C., & Roberts, A. (2005). Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial. Academic emergency medicine: official journal of the Society for Academic Emergency Medicine, 12(4), 282–288.
  2. Smith, H. S. (2009, July). Opioid metabolism. In Mayo Clinic Proceedings (Vol. 84, No. 7, pp. 613-624). Elsevier.
  3. Kamble, S. H., Sharma, A., King, T. I., León, F., McCurdy, C. R., & Avery, B. A. (2019). Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica, 49(11), 1279-1288.