Drug Interactions, Kratom Guides

Can You Mix Kratom & Oxycodone (OxyContin)?

Mixing Oxycodone (OxyContin) and kratom (Mitragyna speciosa) is very dangerous.

Kratom and oxycodone help relieve pain but don’t combine them.

Taking these two substances together can lead to significant issues, including overdose.

Oxycodone is dangerous in large amounts. Kratom can slow oxycodone’s metabolization and potentiate its effects, both of which can be deadly.

If you’re considering taking kratom and oxycodone together, be sure to talk to your doctor first about the safe dose of both substances.

Medically reviewed by Dr. Devin Carlson

Last updated 5 months ago by Wade Paul

Can You Mix Kratom & Oxycodone (OxyContin)?

Does Kratom Interact With Oxycodone (OxyContin)?

Kratom is very likely to have a negative interaction with oxycodone.

Taking these substances together can increase the side effects of each. Oxycodone uses CYP3A4 as one of its major metabolic pathways [1].

Kratom also relies upon CYP3A4 during metabolization [2]. They also interact with opioid receptors, causing similar effects. Oxycodone and other opioids can slow breathing and cause extreme sleepiness.

Taking oxycodone and kratom together may increase your risk of overdosing. This becomes more notable when you take them together frequently.

Kratom & Opiate (Narcotic) Analgesics

Oxycodone and other opioids work by changing the way the nervous system and brain respond to pain. 

Any substance classified as an opiate (narcotic) analgesic is dangerous. Mixing opioids and kratom is NOT a good idea.

If you still want to explore kratom and oxycodone together, be sure to speak with your doctor first. 

Other related opiates that kratom may interact with include:

  • Codeine
  • Fentanyl (Actiq, Abstral, Duragesic, Fentora)
  • Hydrocodone (Hysingla, Zohydro ER)
  • Hydrocodone/acetaminophen (Lorcet, Lortab, Norco, Vicodin)
  • Hydromorphone (Dilaudid, Exalgo)
  • Meperidine (Demerol)
  • Methadone (Dolophine, Methadose)
  • Morphine (Kadian, MS Contin, Morphabond)
  • Oliceridine (Olynvik)
  • Oxycodone and acetaminophen (Percocet, Roxicet)
  • Oxycodone and naloxone

Is It Safe to Take Kratom With Oxycodone (OxyContin)?

No, it’s not safe to mix oxycodone with kratom.

Because these substances have a negative interaction, they will increase the effects of each other. This is very dangerous as it could cause you to overdose or even die.

Before mixing kratom and oxycodone, be sure to speak to your doctor first. 

What is Oxycodone?

Oxycodone was first discovered in Germany in 1916. Due to how well it can treat pain, this drug is on the List of Essential Medicines by the World Health Organization.

Oxycodone can treat pain that doesn’t respond to other medications. It works quite well, and it doesn’t have as many side effects as morphine.

In the U.S., oxycodone has been approved to treat children as young as 11. As of 2019, it has become the 49th most popular prescription medication. More than 14 million people have an active prescription for oxycodone.

Oxycodone was responsible for 11.1% of all opioid deaths in Ontario [3].  

Oxycodone Specs:

Trade NameRoxicodone, OxyContin, Oxaydo, & Xtampza ER
ClassificationOpiate (narcotic) analgesics
CYP MetabolismCYP3A4
Interaction with KratomAgonistic interaction 
Risk of InteractionModerate to high

What is Oxycodone Used for?

Oxycodone is used for moderate to severe pain. Opioid withdrawal can occur if you stop taking it without weaning yourself off it.

What Are the Side Effects of Oxycodone?

If you are allergic to codeine, you may also be allergic to oxycodone. 

Common side effects of oxycodone may include:

  • Constipation
  • Nausea
  • Vomiting
  • Somnolence
  • Dizziness
  • Itching
  • Dry mouth
  • Sweating
  • Reduced sensitivity to pain
  • Delayed gastric emptying
  • Euphoria
  • Anxiolysis
  • Feelings of relaxation
  • Respiratory depression
  • Loss of appetite
  • Nervousness
  • Abdominal pain
  • Diarrhea
  • Urinary retention
  • Dyspnea
  • Hiccups

What Is Kratom?

Kratom is from Southeast Asia. It is part of the coffee family and has been used since at least the 19th century. Its leaves are chewed or dried then powdered.

Kratom has stimulant-like effects and opioid properties. Because of this, it’s commonly used for opioid withdrawal, pain, and energy.

What’s Kratom Used for?

In Southeast Asia, kratom is still used as traditional medicine. It’s quickly becoming more popular in the rest of the world, primarily because of its medicinal properties though some people use it recreationally.

Health benefits of kratom include:

What’s the Dose of Kratom?

If you’re new to taking kratom, it’s best to stick around 2 grams. As you get more used to it, you can increase the amount. This varies from person to person.

General dosage guidelines for kratom include:

  • Low-Dose Kratom (2–6 grams of dried powder)
  • High-Dose Kratom (6–12 grams of dried powder)

Some people become addicted to kratom and may go through withdrawal if they quit taking it. The good news is that if you don’t take more than 12 grams, your odds of this will be significantly lower.

Related: How Long Should I Wait Between Kratom Doses?

What are the Side Effects of Kratom?

Kratom is well-tolerated by most users. Despite this, you may still experience one or more side effects. The best way to avoid these is by sticking with low amounts. The risk of side effects, including addiction, increases if you use too much kratom or use it too often.

Common side effects of kratom include:

  • Constipation
  • Dizziness
  • Anxiety
  • Brain fog
  • Cognitive impairment
  • Nausea
  • Vomiting
  • Sedation
  • Lethargy

What Are the Different Types of Kratom?

Kratom can be found in a wide variety of different strains. Each of these strains belongs to one of four classes: white, red, green, and yellow.

Here’s a quick run-down of the different kratom strain classes:

  1. White Vein Kratom — Best for concentration, energy, and focus. Effects are energizing and euphoric.
  2. Red Vein Kratom — Best for pain and sleep, fast-acting and powerful. Effects are relaxing and numbing.
  3. Green Vein Kratom — Balanced between white and red (stimulating and sedating).
  4. Yellow Vein Kratom — Made from a combination of white kratom and other strains. Effects cover all ranges of the spectrum (stimulating or sedating).
Mitragyna speciosa korth wrapper for eating isolated from white background. leaves of Mitragyna speciosa (Kratom).

Key Takeaways: Is it Safe to Mix Kratom & Oxycodone (OxyContin)?

Oxycodone and kratom should not be used together.

Due to their agonistic interaction, these two substances will likely increase each other’s effects. This could cause an overdose and death.

The longer you take oxycodone and kratom together, the greater your odds of suffering from severe side effects.

Speak to your doctor before you decide to mix kratom and oxycodone.   


  1. Löfdal, K. C. S., Andersson, M. L., & Gustafsson, L. L. (2013). Cytochrome P450-mediated changes in oxycodone pharmacokinetics/pharmacodynamics and their clinical implications. Drugs, 73(6), 533-543.
  2. Kamble, S. H., Sharma, A., King, T. I., León, F., McCurdy, C. R., & Avery, B. A. (2019). Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica, 49(11), 1279-1288.
  3. Dhalla, I. A., Mamdani, M. M., Sivilotti, M. L., Kopp, A., Qureshi, O., & Juurlink, D. N. (2009). Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. Cmaj, 181(12), 891-896.