Drug Interactions, Kratom Guides

Kratom & Hydrocodone (Oxycontin): Is It Safe To Mix?

Does Kratom Interact With Hydrocodone?

Kratom and hydrocodone are known to interact with each other. 

Both substances interact with the opioid receptors and will increase each other’s effects (agonistic reaction) [1]. 

Sedatives can also have an interaction with hydrocodone, which means that mixing certain kratom strains with it could be worse than others. You may wish to avoid taking any red vein kratom strains with hydrocodone to be on the safe side. 

Kratom & Opioids

Oxycodone (OxyContin) is classified as an opioid, which means it binds and activates the opioid receptors in the central nervous system. There are dozens of other opioid medications, all of which will share a similar level of risk when used alongside kratom. 

Kratom should never be used in combination with opioid medications unless otherwise specified by your prescribing doctor. 

Other related opioids kratom will interact with include: 

  • Buprenorphine (Cizdol & Brixadi)
  • Codeine
  • Pethidine (Meperidine & Demerol)
  • Fentanyl (Abstral & Actiq)
  • Hydromorphone (Dilaudid)
  • Methadone (Methadose & Dolophine)
  • Morphine (Kadian & Roxanol)
  • Oxycodone (Percodan, Endodan, Roxiprin, Percocet, Endocet, Roxicet & OxyContin)
  • Tramadol (Ultram, Ryzolt & ConZip)

Is it Safe to Take Kratom With Hydrocodone?

From a medical standpoint, this question remains unanswered. We do know that there have been some interactions between kratom and hydrocodone, though.  

Hydrocodone is an opioid [2], which can have a negative interaction with kratom. 

Be sure to let your doctor know if you’re planning on taking both substances. They can give you the best professional advice considering your particular case. Additionally, they’ll be able to help you monitor yourself for potential interactions. 

What is Hydrocodone?

Hydrocodone should only be taken when no other pain relievers work. It can be habit-forming and should never be taken differently than prescribed. 

Hydrocodone (OxyContin) Specifications:

Drug Name Hydrocodone
Trade Name OxyContin, Zohydro ER, Hysingla ER
Other Names (generics) Dihydocodeinone, Hydrocodone Bitartrate
Classification  Opiate Analgesic 
CYP Metabolism  CYP2D6, CYP3A4
Interaction with Kratom  Agonistic Interaction 
Risk of Interaction  Moderate 

What is Hydrocodone Used For?

Hydrocodone is used for severe pain. It is exclusively prescribed to those who will have around-the-clock pain yet won’t respond well to any other pain medication. In some instances, it may also be used as a cough suppressant. 

What’s the Dose of Hydrocodone?

There are two different versions of hydrocodone: extended-release capsules and extended-release tablets. The capsule is generally taken every 12 hours. The tablet is typically taken once per day. 

The dosage for hydrocodone can vary between 5 mg and 60 mg.   

Generic & Brand Name Versions

Hydrocodone comes in a variety of different names. It’s usually offered as dihydrocodeine or hydrocodone bitartrate.

Several different medications combine hydrocodone with other medications, including acetaminophen, ibuprofen, and aspirin. Please note that there may be different side effects and interactions if you’re taking these pills instead of regular hydrocodone.

What Are the Side Effects of Hydrocodone?

Mild to moderate side effects of hydrocodone may include: 

  • Dry mouth
  • Stomach pain
  • Headache
  • Tiredness
  • Muscle tightening 
  • Back pain
  • Ringing in the ears
  • Difficult, painful, or frequent urination 
  • Ankle, leg, or foot swelling 
  • Uncontrollable shaking 
  • Hard time falling or staying asleep 

Serious side effects may include: 

  • Chest pain
  • Nausea or vomiting 
  • Hallucinations and/or agitation 
  • Sweating, fever, and/or confusion 
  • Fast heartbeat
  • Shivering
  • Loss of coordination 
  • Severe muscle twitching or stiffness 
  • Diarrhea 
  • Loss of appetite 
  • Dizziness or weakness
  • Erectile disfunction 
  • Irregular menstruation 
  • Swollen throat, tongue, lips, face, or eyes 
  • Changes in heartbeat
  • Hoarseness 
  • Itching and/or hives 
  • Difficulty breathing or swallowing 
Kratom (Mitragyna speciosa)

What is Kratom?

Kratom is a plant that originated in Southeast Asia. It has been used since at least the 19th century, but it most likely goes back much further. It offers pain relief in high doses and works as a sedative in lower doses. 

What’s Kratom Used For?

Kratom leaves are chewed in Southeast Asia. You can also use kratom as a powder, brew kratom leaves into a tea, or smoke them

Kratom is used to treat a variety of different problems, ranging from insomnia and anxiety to elevating mood and enhancing physical endurance

What’s The Dose of Kratom?

Depending on what you need it for and how much experience you have, your ideal kratom dosage might vary. 

However, the general kratom dosage guidelines are: 

  • Low-Dose Kratom (2 to 6 grams) 
  • High-Dose Kratom (6 to 12 grams)

Be sure not to take more than 12 grams at a time since you could experience kratom’s side effects.

Related: Can You Overdose on Kratom?

What are the Side Effects of Kratom?

  • Nausea 
  • Insomnia
  • Hyperpigmentation 
  • Dizziness
  • Poor appetite 
  • Low libido 
  • Tremors or muscle contractions 
  • Dizziness 
  • Itchy skin
  • Low blood pressure 
  • Seizures 

What are the Different Types of Kratom?

  1. White Vein Kratom The most stimulating strain, boosts motivation and mood. 
  2. Red Vein Kratom Sedating and relaxing helps with sleep and pain relief.  
  3. Green Vein Kratom A balanced strain that’s stimulating, used for anti-anxiety and sleep.
  4. Yellow Vein Kratom Weaker than the white vein, enhances mood, improves concentration. 

Key Takeaways: Is it Safe to Mix Kratom & Hydrocodone?

Hydrocodone and kratom are known to have some interactions. This is especially dangerous when hydrocodone is mixed with kratom as an adulterant. 

They are both known to cause liver issues and may increase each other’s effects — leading to a higher chance of side effects. 

Always speak to your doctor before you begin taking hydrocodone and kratom together. They can help you determine if the rewards outweigh the risks.  


  1. Marco, C. A., Plewa, M. C., Buderer, N., Black, C., & Roberts, A. (2005). Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial. Academic emergency medicine: official journal of the Society for Academic Emergency Medicine, 12(4), 282–288.
  2. Habbouche, J., Lee, J., Steiger, R., Dupree, J. M., Khalsa, C., Englesbe, M., … & Waljee, J. (2018). Association of hydrocodone schedule change with opioid prescriptions following surgery. JAMA Surgery, 153(12), 1111-1119.