Drug Interactions, Kratom Guides

Want To Know How Phenobarbital (Luminal) & Kratom Interact? We’ve Got You Covered

Does Kratom Interact With Phenobarbital (Luminal)?

Yes — even though this interaction is unusual, it can still be dangerous. Combining kratom and barbiturates like phenobarbital can be high-risk.

Phenobarbital (Luminal) is a CYP450 enzyme inducer. In practical terms, this means that phenobarbital increases the effectiveness of CYP450 enzymes, speeding up the removal of drugs that are metabolized by the CYP system, like kratom.

In other words, phenobarbital has a metabolic reaction with kratom that makes kratom’s effects less effective.

Because phenobarbital suppresses the central nervous system, it’s too easy to overdose on it. It’s best to avoid any drugs that could inhibit its metabolization, like kratom.

Is it Safe to Take Kratom With ​​Phenobarbital (Luminal)?

Kratom and phenobarbital’s interaction can still cause unintended effects. Because phenobarbital (Luminal) is a barbiturate, it’s best to be extremely cautious and avoid using kratom with the drug. Consult with your doctor before combining kratom and medications.

What is Phenobarbital?

Phenobarbital, also known by its trade name Luminal, is a barbiturate medication.

Barbiturates are a class of compounds derived from barbituric acid.

Phenobarbital is registered by the DEA as a Schedule IV compound, meaning it has legitimate medical uses but carries a low potential for abuse, which can turn into dependence.

Discovered in 1912, phenobarbital is one of the oldest seizures medications still in use.

Phenobarbital Specs

Drug NamePhenobarbital
Trade NameLuminal
CYP MetabolismPhenobarbital is metabolized in the liver, mostly by CYP2C19
Interaction With KratomMetabolic; possibly agonistic
Risk of InteractionModerate to high

What is Phenobarbital Used for?

Phenobarbital mainly treats all types of seizures [1].

However, even though phenobarbital has proven effectiveness in treating seizures, it has mostly been replaced by medications that cause fewer adverse effects.

Phenobarbital is also commonly used for other purposes:

  • Doctors have been known to prescribe phenobarbital to treat anxiety-related conditions [2].
  • Phenobarbital has been used to treat withdrawal symptoms stemming from different types of drug use [3].
  • Lastly, phenobarbital can also help treat issues related to insomnia and anxiety [4].

What’s the Dose of Phenobarbital?

Due to the factors that assess proper dosage, it’s best to contact your doctor if you’re having doubts about your phenobarbital prescription.

Phenobarbital has specific difficulties that only a qualified medical professional can deal with, such as an unusually long half-life. It also has several contraindications that might make it potentially dangerous.

Generic & Brand Name Versions

Some of the brand names for phenobarbital are:

  • Luminal
  • Solfoton
  • Tedral
  • Donnatal

What Are the Side Effects of Phenobarbital

Common side effects associated with phenobarbital include [1]:

  • Loss of coordination
  • Impaired balance
  • Drowsiness
  • Irritability

Rarer, but more serious side effects are:

  • Coma
  • Decreased effort to breathe
  • Low blood pressure
  • Steven-johnson syndrome
  • Suicidal ideation

Long-term use of phenobarbital has been associated with:

  • Bone aches
  • Depression
  • Liver
  • Depression

What is Kratom?

Kratom is a plant-based psychoactive with a wide range of benefits.

It is harvested from the leaves of the Mitragyna speciosa, a species of a tropical evergreen tree native to Southeast Asia. Local farmers and indigenous people have used kratom for centuries, even though it’s just becoming known in the west.

Kratom owes its magnificent properties to the natural alkaloid compounds that are found inside it. The two most important are mitragynine and 7-hydroxymitragynine.

Kratom acts on the body’s opioid receptors, giving it potent painkilling abilities but is much safer.

What is Kratom Used for?

As mentioned before, kratom has a vast spectrum of uses.

When consumed in low doses, kratom acts as a stimulant and can produce powerful cognitive benefits, just like coffee and the coca leaf!

Small amounts can stimulate euphoria and promote mental and physical energy.

However, the larger the amount, the more the effects change. It goes from stimulant-like properties into providing potent analgesic and anti-anxiety benefits.

Other more singular uses for kratom have also been discovered:

What’s the Dose of Kratom?

You should always be aware that formulaic dosage recommendations found on the internet can never be totally accurate. There’s just no way they can take into account all the ways humans differ.

However, it’s still useful to know the general dosage range.

Standard kratom dose is as follows:

  • Low dose — 1-4 grams
  • Medium dose — 4-8 grams
  • High dose — 8-12 grams

For additional info, check out our kratom dosing guide.

What Are the Side Effects of Kratom?

Kratom, like all drugs, has its fair share of side effects:

  • Constipation
  • Dizziness
  • Insomnia
  • Nausea
  • Itchiness
  • Loss of muscle coordination

The following are far less common, but something to watch out for — these generally mean you took too much or need a long break.

  • Low blood pressure
  • Low libido
  • Nausea
  • Poor appetite
  • Seizures
  • Tremors

Kratom can also cause symptoms of mental and physical dependence.

Kratom addiction is less likely when compared to pharmacological drugs like antidepressants or painkillers, but it’s always a possibility.

Make sure to become familiar with the dangers of kratom use.

What Are the Different Types of Kratom?

The kratom plants have four different types of strains: excellent news for those who like to experiment and tinker.

However, it’s not like they’re entirely different from one another. All kratom strains share the same basic spectrum of effects.

Their uniqueness is due to the fact that each strain is better at emphasizing a different part of said spectrum.

A) White Vein Kratom

White vein kratom is the way to go if you want to focus on kratom’s cognitive benefits.

A white-veined kratom strain is a great option to replace your morning coffee!

B) Red Vein Kratom

Red vein kratom is extremely popular with those suffering from chronic pain or anxiety. This is because red-veined kratom strains are known to be relaxing and more potent pain-relievers.

C) Green Vein Kratom

Green vein kratom is a little different than white or red kratom. Instead of focusing on one end of the kratom spectrum, it provides a well-balanced experience with all of what kratom offers.

D) Yellow Vein Kratom

Yellow vein strains are pretty much the same as green, the only difference being that they are much lighter: perfect for first-timers or those who have a sensitivity!

Key Takeaways: Is it Safe to Mix Kratom & Phenobarbital

It’s best to avoid using kratom with barbiturates — this combination could come with some high risks. Speak to your doctor first if you feel you could benefit from using kratom and phenobarbital.

Phenobarbital can also make your kratom less potent, and since phenobarbital has a half-life of unusually long duration, you might want to replace kratom with a compound that won’t have its potency reduced.


  1. Lewis, C. B., & Adams, N. (2021). Phenobarbital. StatPearls.
  2. Mula, M., Pini, S., & Cassano, G. B. (2007). The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence. Journal of clinical psychopharmacology, 27(3), 263-272.
  3. Nisavic, M., Nejad, S. H., Isenberg, B. M., Bajwa, E. K., Currier, P., Wallace, P. M., … & Wilens, T. (2019). Use of phenobarbital in alcohol withdrawal management–a retrospective comparison study of phenobarbital and benzodiazepines for acute alcohol withdrawal management in general medical patients. Psychosomatics, 60(5), 458-467.
  4. Prinz, P. N., Vitiello, M. V., Roehrs, T. A., Linnoila, M., & Weitzman, E. D. (1981). Effect of phenobarbital on sleep and nighttime plasma growth hormone and cortisol levels. Canadian journal of physiology and pharmacology, 59(11), 1139-1145.