Drug Interactions, Kratom Guides

Can You Mix Kratom and Percocet (Oxycodone & Acetaminophen)?

Mixing Percocet and kratom (Mitragyna speciosa) is very dangerous. 

If you take these two together – especially on a regular basis – they may increase your risk of dealing with severe side effects. Additionally, mixing Percocet and kratom may increase your risk of an overdose. 

Before you begin taking kratom and Percocet together, be sure to talk to your doctor.

Last updated 3 days ago by Audrey Webber

Can You Mix Kratom and Percocet (Oxycodone & Acetaminophen)?

Does Kratom Interact With Percocet?

Kratom has a high chance of interacting negatively with Percocet. 

Percocet uses CYP3A4 as its major metabolic pathway [1]. Kratom also uses CYP3A4 during metabolization [2]. Taking these two substances together may increase the side effects of each

Taking Percocet and kratom together may also increase your risk of overdosing. This is especially prevalent if you take them together frequently.     

Similar Interactions With Kratom To Be Aware Of

Percocet contains a combination of oxycodone and acetaminophen. In other words, it combines an opioid pain medication with an NSAID analgesic

This is a dangerous class of drugs. You should be very careful if you decide to mix any of them together. 

Speak to your doctor about your plans.  

Other related analgesics, and opioid combos that kratom may interact with include:

Is It Safe to Take Kratom With Percocet?

No, it’s not safe to mix Percocet with kratom

The two substances work together to make each other stronger. Therefore, you’ll face a much higher risk of side effects and/or an overdose. 

Talk to your doctor to determine if this combo is right for you.

What is Percocet?

The FDA first approved Percocet in 1976. This combination of oxycodone and acetaminophen treats moderate to severe pain. 

In 2009, the FDA recommended that Percocet, along with all other combinations of narcotic analgesics and acetaminophen, should be limited in sales. At the time, there were approximately 400 deaths blamed on Percocet annually. 

This particular medication was linked to a fivefold increase in deaths in Ontario over all other opioids [3].   

Percocet Specs:

Trade NameOxycodone & acetaminophen  
ClassificationAnalgesics, opioid combo
CYP MetabolismCYP3A4
Interaction with KratomAgonistic interaction  
Risk of InteractionModerate to high 

What is Percocet Used For?

Percocet is used for moderate to severe pain. Do not eat grapefruit or drink grapefruit juice when you use this medication.     

What Are the Side Effects of Percocet?

Percocet can produce many unpleasant side effects. This is especially notable if you have serious or very serious side effects.  

Common side effects of Percocet may include:

  • Adrenal glands not working well
  • Constipation 
  • Difficulty urinating
  • Dizziness
  • Drowsiness
  • Fainting 
  • Itching/swelling (face/tongue/throat)
  • Lightheadedness
  • Mental/mood changes
  • Nausea
  • Rash
  • Seizure 
  • Severe dizziness
  • Severe drowsiness/difficulty waking up
  • Severe stomach/abdominal pain
  • Sleep apnea 
  • Slow/shallow breathing
  • Trouble breathing 
  • Vomiting 

What is Kratom?

Kratom is a member of the coffee family. It hails from Southeast Asia and is found in Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea.  

Kratom has been used since at least the 19th century. Its primary usage is to increase energy, especially among laborers in Southeast Asia. It also has a wide variety of other uses, including opioid withdrawal.   

What’s Kratom Used For?

Kratom is still used for medicinal purposes in Southeast Asia. Additionally, it’s used recreationally throughout much of the world.   

Suggested health benefits of kratom include: 

What’s The Dose of Kratom?

Anyone who is a newcomer to kratom would be wise to stick with a low dose. Around 2 grams is suggested as a good dose. Those who have more experience with kratom may wish to use a low or high dose. 

General dosage guidelines for kratom include: 

  • Low-Dose Kratom (2–6 grams of dried powder)
  • High-Dose Kratom (6–12 grams of dried powder)

Taking more than 12 grams at a time may increase your odds of dealing with side effects and/or an overdose. To avoid this issue, take 12 grams or less. 

What are the Side Effects of Kratom?

Kratom is generally regarded as being well-tolerated. However, this doesn’t mean that you won’t possibly deal with some side effects. 

Common side effects of kratom include: 

What are the Different Types of Kratom?

Kratom can be found in dozens of different strains. Each of these strains belongs to one of four classes: white, red, green, and yellow. 

Here’s a quick run-down of the different kratom strain classes

  1. White Vein Kratom — Best for focus, energy, and concentration. The effects are euphoric and energizing. 
  2. Red Vein Kratom — Best for sleep and pain, fast-acting and powerful. Effects are numbing and relaxing. 
  3. Green Vein Kratom — Balanced between white and red (sedating and stimulating).
  4. Yellow Vein Kratom — Made from a combination of white kratom and other strains. Effects cover all ranges of the spectrum (sedating or stimulating). 

Key Takeaways: Is it Safe to Mix Kratom & Percocet

Percocet and kratom should never be used together

Because they have an agonistic interaction, mixing them could cause your risk of side effects and/or an overdose to go up. 

If you’re taking Percocet and wish to add kratom into the mix, be sure to speak with your doctor first. 

Don’t forget that Percocet and kratom have a higher chance of a negative interaction if you take these two substances together regularly.   


  1. Löfdal, K. C. S., Andersson, M. L., & Gustafsson, L. L. (2013). Cytochrome P450-mediated changes in oxycodone pharmacokinetics/pharmacodynamics and their clinical implications. Drugs, 73(6), 533-543.
  2. Kamble, S. H., Sharma, A., King, T. I., León, F., McCurdy, C. R., & Avery, B. A. (2019). Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica, 49(11), 1279-1288.
  3. Dhalla, I. A., Mamdani, M. M., Sivilotti, M. L., Kopp, A., Qureshi, O., & Juurlink, D. N. (2009). Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. Cmaj, 181(12), 891-896.

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