Does Kratom Interact With Agmatine (AgmaSet)?
Kratom can interact indirectly with agmatine by increasing its effects. While this might sound good, it can actually be dangerous and causes a greater risk of side effects, such as drowsiness, depression, and anxiety.
This interaction is considered moderate but differs from person to person, especially if the two drugs are taken for long and in large quantities.
Always get proper consultation from your physician before taking kratom and agmatine together.
Kratom and agmatine can interact agonistically. While a milder form of interaction could help mitigate pain better, a more severe form could cause effects like excess drowsiness, a potentially dangerous side effect if you’re doing activities that require absolute concentration.
Agmatine can also increase the chances of experiencing anxiety and depression. Overuse of kratom can also cause these effects .
Agonistic interaction happens by mixing two substances that give similar effects. These substances might act on the same or different receptors but produce some effects in the same direction when taken together.
Both the drugs have similar actions, so taking them together can cause their pain-relieving abilities to increase, causing side effects like sedation. You can avoid this by using small quantities of both drugs for a short duration.
Because these two medications are metabolized in different ways, there are minimum chances of any metabolic competition occurring in the body between them.
Agmatine is classified as a guanidine, which means it exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels, nitric oxide (NO) synthesis, and polyamine metabolism. There are a few other aminoguanidine medications, all of which share a similar level of risk when used alongside kratom.
Other guanidines that kratom interacts with include:
Kratom and agmatine can have moderate levels of interaction when taken together. They may be safe to consume together in short amounts and for a short time. Agmatine can help to increase the relaxing and pain-relieving properties of kratom.
However, the long time consumption of both drugs with high dosages may cause the two drugs to have more powerful effects, leading to some unwanted effects.
There are no studies on how these two interact. Since we don’t know the exact amounts or how long it takes to cause a dangerous interaction, don’t take these medications until after you consult your physician. Never start them of your own accord; if you encounter any unusual side effects, get medical aid immediately.
Agmatine is an aminoguanidine and a metabolite of the amino acid arginine that occurs naturally.
Agmatine can regulate many critical molecular targets of essential systems in the body. It is being studied to treat depression, high blood pressure, and nerve pain and helps build up muscles in bodybuilding and improve athletic performance. It also has the properties of neuromodulators, helping to transmit information across neurons.
It is found in ragweed pollen, ergot fungi, octopus muscle, herring sperm, sponges, and mammalian brains when arginine is decarboxylated by the enzyme arginine decarboxylase.
Agmatine Details & Specifications:
|Trade Name||AgmaSet, Transparent Labs RawSeries Agmatine, Nutricost Agmatine, BulkSupplements Pure Agmatine Sulfate Powder, Hard Rhino Agmatine Sulfate Powder|
|CYP Metabolism||Not specified|
|Interaction With Kratom||Agonistic|
|Risk of Interaction||Moderate|
Agmatine is being studied for several indications. Some of these are:
Research shows agmatine has neuroprotective effects against brain edema following transient cerebral ischemia . The potential mechanisms for this include anti-oxidation, anti-apoptosis, and anti-inflammation properties of agmatine . It may also be effective in stroke, severe CNS injuries, epilepsy, glaucoma, neuropathic pain, and psychiatric conditions such as depression, anxiety, schizophrenia, and cognition.
Agmatine has a cardioprotective function and may help reduce the effects of ischemic heart disease . Agmatine can act directly on endothelial cells and increase nitric oxide synthesis, a substance that can cause vasodilation. This property may also help to lower blood pressure.
It is being studied for use in patients with small fiber peripheral neuropathy . It can reduce neuropathic pain caused by small fiber neuropathy (SFN), which is resistant to conventional neuropathic pain medications.
It may also decrease dependence in people who use opioids . Agmatine can block the physical dependence on morphine by acting on the cAMP signaling pathway. This means it can prevent or reduce opioid-induced tolerance and self-administration amongst opioid users.
Agmatine can improve insulin sensitivity by stimulating the adrenal gland and enhancing beta-endorphin secretion . It also activates peripheral I2-imidazoline receptors in tissues, which helps improve the actions of insulin. Thus, it can help to reduce high blood glucose levels as well.
Agmatine can increase the luteinizing hormone (LH) levels, which, in turn, can increase testosterone levels and help build more muscles during training .
The recommended dose of agmatine is 1.6 mg to 6.4 mg per kilogram of bodyweight.
- BulkSupplements Pure Agmatine Sulfate Powder
- Hard Rhino Agmatine Sulfate Powder
- Nutricost Agmatine
- Transparent Labs RawSeries Agmatine
- Gastrointestinal disturbances
- Increased anxiety and depression
- Increased appetite
- Upset stomach
It was traditionally used for medicine and was considered a household staple but only recently made its way to the Western world.
It’s a unique plant because, in low doses, it acts as a stimulant, but in high doses, it can act as a sedative. Large amounts are more likely to cause side effects and addiction.
There are many uses for kratom, but here are the most common.
The kratom dose is based on what effects you want. If you’re seeking pain relief or struggle to sleep, you’ll want higher doses — 5-10 g. If energy, concentration, and improved mood are what you’re after, stick with smaller amounts — 2-5 g. You can even try microdosing if you want (less than 2 g).
The key is to only use as much as you need and when you really need it. Too much kratom too often leads to an increased risk of side effects and addiction. Take breaks from it now and then to avoid building a tolerance.
Kratom is relatively safe and has few side effects that are worth noting. Still, they exist, and it helps to know what to expect.
Common side effects include:
- Dry mouth
- Frequent urination
- Heart palpitations
- Liver damage
- Loss of appetite
- Withdrawal symptoms with long-term use
You might become overwhelmed if you buy kratom and know nothing about it. Many strains are available, and it’s hard to know which one does what and why they’re different.
Don’t worry — it’s actually quite simple. Kratom is divided into strains based on the veins in the leaves. The alkaloid content determines the color and greatly affects the effects. There are three primary colors, and we’ll go over each one.
White Vein Kratom
White strains boost concentration power, energy, and mood and can even help raise cognition. People use white strains to help with depression, though they can cause anxiety in some people.
Red Vein Kratom
Red strains are calming, can decrease anxiety, and help with insomnia. They have strong pain-relieving action due to their interaction with the opioid system.
Green Vein Kratom
Green strains are a balance between red and white. They have both stimulant and sedative effects that can alter with the amount of dosing. All kratom has this ability, but it’s more pronounced with green. These are ideal for anyone new to kratom or who doesn’t want anything too extreme.
Yellow Vein Kratom
Kratom and agmatine can interact moderately with each other. Their interaction is agonistic since both drugs are pain relievers. Taking them together in small doses could help lighten the pain better.
However, this interaction can worsen with long-term medication or high doses, leading to sedation-like effects that could become dangerous.
Because of the potential for danger, it’s always best to talk to your prescribing physician before you begin.
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- Huang, Y. C., Tzeng, W. S., Wang, C. C., Cheng, B. C., Chang, Y. K., Chen, H. H., … & Chang, C. P. (2013). Neuroprotective effect of agmatine in rats with transient cerebral ischemia using MR imaging and histopathologic evaluation. Magnetic Resonance Imaging, 31(7), 1174-1181.
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- Kalra, S. P., Pearson, E., Sahu, A., & Kalra, P. S. (1995). Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro. Neuroscience letters, 194(3), 165-168.
- Xu, W., Gao, L., Li, T., Shao, A., & Zhang, J. (2018). Neuroprotective role of agmatine in neurological diseases. Current neuropharmacology, 16(9), 1296-1305.
- Gawali, N. B., Bulani, V. D., Gursahani, M. S., Deshpande, P. S., Kothavade, P. S., & Juvekar, A. R. (2017). Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway. Brain research, 1663, 66-77.