Drug Interactions, Kratom Guides

Kratom and Folic Acid: How Do They Interact?

Does Kratom Interact With Folic Acid?

No, kratom and folic acid are unlikely to interact in any meaningful way.

Folic acid does not exert any psychotropic effects on the user. This means it will not interact with kratom’s many psychoactive effects. It also won’t affect kratom’s other properties like its analgesic and anxiolytic benefits.

Also, kratom and folic acid have distinct metabolic pathways and do not induct or inhibit themselves in this sense.

Is it Safe to Take Kratom With Folic Acid?

Yes, there is no reason why folic acid consumption will make kratom more dangerous.

Taking kratom by itself still carries certain risks, though, and you certainly still have to be mindful of them.

However, you can rest easy knowing that folic acid supplementation will not increase your risk level when taking kratom.

What is Folic Acid?

Folic acid — the manufactured form of folate — is one of the B vitamins.

B vitamins are a class of essential nutrients that play several important roles in crucial bodily processes such as cell metabolism and the synthesis of red blood cells. There are many different B vitamins; folic acid corresponds to vitamin B9.

Humans are unable to produce folic acid, and because of this, we must ingest it via our diet or through supplementation. Folate can be found in asparagus, Brussel sprouts, dark leafy greens, animal liver, and walnuts.

Not consuming enough folate can lead to several health problems like anemia, increased risk of birth defects, symptoms of tiredness, heart palpitations, and more [1].

Many countries have mandated the fortification of certain foods with folic acid to decrease folate deficiencies.

The recommended adult daily intake of folic acid is 400 micrograms.

Folic Acid Specs:

Nutrient NameFolic Acid
Trade NamesFolicet, Folvite
ClassificationB vitamin
CYP MetabolismFolic acid metabolism is not CYP mediated
Interaction With KratomNone
Risk of InteractionVery Low Risk

What is Folic Acid Used for?

Folate is essential for many vital processes and folic acid has thus received FDA approval for several indications [2]:

  1. The body needs folate to make DNA as well as RNA
  2. Metabolize amino acids necessary for cell division (very important in times of frequent growth like pregnancy and infancy)
  3. Prevention of birth defects, especially neural tube defects
  4. Fertility: folate contributes to spermatogenesis, and in women, it is key for oocyte quality
  5. Moderate reduction of heart disease risk
  6. Moderate decrease in the risk of a stroke
  7. Moderate decrease in the risk of cancer

In general, a folate deficiency can lead to a staggering amount of health issues. The primary purpose of folic acid is to supplement folate in the body and prevent such ailments from arising.

Generic & Brand Name Versions

Folic acid can be found under the following brand names:

  • Folvite
  • Folacin
  • FA-8

What’s the Dose of Folic Acid?

The proper dosage of folic acid depends mainly on age, but there are some additional factors like pregnancy.

  1. Adult and teenage males — 150 to 400 micrograms (mcg) per day.
  2. Adult and teenage females — 150 to 400 mcg per day.
  3. Pregnant females — 400 to 800 mcg per day.
  4. Breast-feeding females — 260 to 800 mcg per day.
  5. Children 7 to 10 years of age — 100 to 400 mcg per day.
  6. Children 4 to 6 years of age — 75 to 400 mcg per day.
  7. Children birth to 3 years of age — 25 to 100 mcg per day.

What Are the Side Effects of Folic Acid?

The mandatory fortification of food with folic acid has raised concerns that certain general population members might be consuming more than the recommended level of folic acid intake. Because of this, several studies have tried to determine if folic acid can cause adverse effects.

Even though there have been discrepancies, the general conclusion has been that folic acid is non-toxic for human beings. There are no established risks or adverse consequences resulting from folic acid intake [3].

However, folic acid can potentially interact with some types of medications like anticonvulsants and barbiturates.

Finally, some studies found it can lead to adverse side effects, although these are usually limited to specific populations like those taking medication for epilepsy.

If you plan to supplement with folic acid, you should still consult with your doctor to avoid any possible harm.

What is Kratom?

Kratom is the common name for the Mitragyna speciosa plant. It’s a tropical evergreen tree native to Southeast Asia and is known for having a vast number of psychoactive benefits.

Like coffee and the coca leaf, kratom has been cultivated for centuries by indigenous peoples, but it’s just becoming popular in the western world. Unfortunately, due to government interference, it is becoming targeted for heavy regulation.

However, that shouldn’t deter you from getting to know this amazing plant because the kratom community is picking up all of the slack!

Organizations like the American Kratom Association are working hard on behalf of kratom’s legality, and there is a vast amount of learning materials and testimonials to be found online.

What is Kratom Used for?

There are two basic types of kratom users: those who enjoy the stimulant or relaxant aspects of the kratom spectrum and those who use kratom as a treatment or alternative to prescription medications (especially in the opiate and benzodiazepine family).

A low dose can make users feel more energized and focused; it can also cause feelings of euphoria.

Kratom has also become a treatment for many types of conditions. Higher doses have analgesic (painkilling) properties and may provide anxiety relief.

Lastly, kratom can help treat the symptoms of opiate withdrawal and is becoming popular as a weight-loss supplement.

What’s the Dose of Kratom?

Finding the right dose might take a little experimenting. It varies from person to person and depends on what you’re using it for. However, here is the standard dosing, but remember to start low.

The average kratom dosages include:

  • Low dose (1 – 5 g)
  • Medium dose (5 – 10 g)
  • High dose (10 – 15 g)

Remember that the more kratom you consume, the likelier you will experience adverse effects. Thankfully, these are usually mild in nature.

What Are the Side Effects of Kratom?

Kratom is known to be able to cause the following side effects:

More serious side effects include:

  • Itchiness in the skin
  • Loss of muscle coordination
  • Low blood pressure
  • Low libido
  • Nausea & vomiting
  • Poor appetite
  • Seizures
  • Tremors

You should also be aware that kratom consumption can cause physical and mental dependence. However, even so, kratom is generally considered to be safe, and it’s a less risky alternative than pharmacological painkillers.

What Are the Different Types of Kratom?

Kratom can be found in four types of strains.

How are these different? Glad you asked.

Kratom’s many strains all share the same properties. However, each strain is better at manifesting a different area of the kratom spectrum.

It’s thought that the area of Southeast Asia also affects the alkaloid profile due to factors like soil composition.

A) White Vein Kratom

White vein kratom will be your best bet if you want to experience the nootropic benefits of the kratom spectrum.

It will energize you immensely and help out with your moods! If you want to replace your morning coffee with something that has a bit more kick — go with white vein kratom!

B) Red Vein Kratom

Red vein kratom is best at stimulating the analgesic and anxiolytic benefits of kratom — perfect for anyone with chronic pain or anxiety!

Many even use red-veined kratom strains as sleeping support.

C) Green Vein Kratom

Green vein kratom is like a mixture of red and white kratom. It has an outstanding balance of benefits and can exemplify the whole breadth of the kratom spectrum.

D) Yellow Vein Kratom

Yellow-vein kratom is similar to green. The only difference is that it’s the mildest out of all the strains. If you have a sensitivity to kratom, give it another chance with a yellow-veined strain.

Key Takeaways: Is it Safe to Mix Kratom & Folic Acid?

Yes, there are no expected interactions between kratom and folic acid.

You shouldn’t be afraid of mixing these compounds, but keep in mind that kratom always carries some risk.

Also, you should be aware that the body can only metabolize a certain amount of folic acid at a time. If you consume too much of it, this will lead to elevated levels of unmetabolized folic acid in the blood.

To avoid overconsumption, check if your country fortifies certain foods with folic acid.


  1. Henry, C. J., Nemkov, T., Casás-Selves, M., Bilousova, G., Zaberezhnyy, V., Higa, K. C., … & DeGregori, J. (2017). Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica, 102(12), 1985.
  2. Merrell, B. J., & McMurry, J. P. (2020). Folic Acid.
  3. Field, M. S., & Stover, P. J. (2018). Safety of folic acid. Annals of the New York Academy of Sciences, 1414(1), 59-71.

Further Reading