Drug Interactions, Kratom Guides

Does Kratom Interact With Methamphetamines?

Kratom can have significant interactions with methamphetamine, leading to unwanted side effects and serious complications.

Meth and kratom are both potent stimulants, and combining them amplifies their stimulative effects.

Generally speaking, taking kratom with meth exacerbates the adverse side effects associated with taking each individually. The most common risks of combining kratom with meth are heart problems like arrhythmia and palpitations, high blood pressure, and extreme anxiety. 

Kratom may also increase the chances of overdosing on meth — so this combination is not advised under any conditions. 

Last updated 5 months ago by Wade Paul

Does Kratom Interact With Methamphetamines?

Does Kratom Interact With Meth?

Yes, kratom interacts with stimulants like methamphetamine. 

Meth is classified as a stimulant, which means it excites the central nervous system, increases heart rate, and often induces a pleasurable euphoric feeling [1]. Methamphetamine is a particularly potent stimulant, although many other stimulants have similar interactions with kratom.

Kratom’s effects are dose-dependent, meaning it behaves differently depending on how much you take. Kratom tends to be a stimulant at low doses, but it typically becomes more sedative at higher doses. 

Is it Safe to Take Kratom With Meth?

Taking kratom with meth is generally not a good idea. Methamphetamine is a powerful stimulant that can be dangerous on its own, but it’s especially hazardous if taken in conjunction with another stimulant like kratom. 

White-vein kratom should definitely be off the table since most white strains are highly stimulating. Some red strains can be mildly stimulating, making it difficult to know which strains are safe unless you’re intimately familiar with the strain in question.

In general, it’s best to avoid using kratom if you’re also taking methamphetamine, as adverse effects are very likely and can be severe.

What is Meth?

Methamphetamine is a highly stimulating drug discovered in 1893 that has garnered a following as a recreational drug for its euphoric effect on users. It is regarded as a dangerous drug due to its addictive properties and relatively low threshold for neurotoxicity [2]. Meth is illegal and is classified as a Schedule II drug.

Methamphetamine Specs:

Drug NameMethamphetamine
Other NamesMeth, Crystal Meth, Desoxyn, Crank, Speed, Chalk, Crystal, Wash, Christina, No-Doze, Scooby Snax, Rocket Fuel, Gak, Dunk, Trash, Ice
CYP MetabolismCYP2C6
Interaction with KratomAgonistic or antagonistic, depending on dose
Risk of InteractionHigh

What is Meth Used for?

Meth is sometimes used in low doses as an alternative treatment for attention deficit hyperactivity disorder (ADHD) in patients who don’t respond to other options. Desoxyn is a prescription form of meth approved in the United States by the FDA to treat ADHD and obesity, but it is used very sparingly.

What’s the Dose of Meth?

Experts recommend initially taking 5 mg of Desoxyn to treat ADHD in both adults and children over six years of age, although you should always consult a doctor for specific recommendations. After the initial dose, 20-25 mg per day is the common range for maintenance.

For obesity, the approved dose is 5 mg taken no less than 8 hours apart, usually after a meal.

There is no recommended dose for recreational use, but most users consume 0.1 g of pure meth or up to about 0.5 g of a lower quality, less potent meth.

Generic & Brand Name Versions

Desoxyn is the only FDA-approved version of methamphetamine.

What Are the Side Effects of Meth?

Unfortunately, there are many side effects that most users experience with methamphetamine. Common side effects of meth include:

  • High blood pressure
  • Arrhythmia
  • Heart palpitations
  • Insomnia
  • Headaches
  • Tremors and shaking 
  • Anxiety and restlessness
  • Dizziness
  • Diarrhea
  • Constipation
  • Dry mouth
  • Heart attack
  • Seizures

What is Kratom?

Kratom is a Southeast Asian herb used in traditional medicine to treat pain, aid sleep, and improve mood [3]. It is not an opioid but has similar effects on the human body, causing intense relaxation, reduced muscle tension, and a moderate sense of euphoria. 

What’s Kratom Used for?

There are no approved medical uses for kratom, but many people use it to treat chronic pain and insomnia. Some red and green strains are used to reduce anxiety and depression, and white-vein kratom is commonly used to boost energy and productivity.

Kratom is also widely used to help reduce withdrawal symptoms from opioid addictions. The leaves of the kratom plant have a similar effect on the body to opioids and can help get previous opioid users through the beginning stages of withdrawal.

What’s the Dose of Kratom?

The best kratom dose for you will depend on the effects you’re looking to achieve.

Low doses of kratom between 1 and 3 grams typically offer stimulating effects that increase alertness and improve mood. 

In moderate doses between 3 and 6 grams, kratom offers a blend of stimulation and sedation, creating a clean, energized feeling similar to combining L-theanine with caffeine. 

In larger amounts, usually between 6 and 10 grams, kratom becomes intensely relaxing, making users feel at ease and content. High doses are considered the best for treating pain and insomnia. 

What Are the Side Effects of Kratom?

Like most herbs and drugs, kratom does have the potential for side effects

The most common side effects of kratom are:

  • Nausea
  • Lethargy
  • Dizziness
  • Constipation
  • Foggy head feeling
  • Anxiety
  • Memory impairment
  • General confusion

Most side effects are experienced when taking higher doses, so most people recommend keeping your dose low if you’re concerned about any of the above.

The most significant potential side effect of kratom use is addiction. Kratom can be habit-forming, so experts recommend limiting your use to 4-5 days per week and taking an extended tolerance break every 1-2 months.

Suggested Reading: How Long Should I Wait Between Kratom Doses?

What Are the Different Types of Kratom?

There are four main varieties of kratom, each with its own effects profile.

A) White Vein Kratom

White-vein kratom is the most energizing family of strains, making users feel awake and alert. Most people describe white-vein kratom as providing about as much energy as 1-2 cups of strong coffee and recommend taking it in the morning. 

B) Red Vein Kratom

Red-vein kratom is the opposite of white-vein in many ways, offering users relaxation and pain relief. This is the strain of choice for people with anxiety or insomnia.

C) Green Vein Kratom

Falling somewhere between white and red-vein kratom, you’ll find green-vein kratom. Many people view green-vein strains as the best of both worlds, providing a balanced blend of calm, clean energy alongside moderate pain relief. 

E) Yellow Vein Kratom

Yellow-vein kratom isn’t really its own strain; rather, it is a unique fermented version of white-vein kratom. The fermentation process replaces the ordinary drying technique and results in strains with higher potency.

Key Takeaways: Is it Safe to Mix Kratom & Meth?

Mixing kratom and meth is not advised. Combining two potent stimulants like meth and kratom can have disastrous results and even cause heart attacks and seizures in extreme cases. 

White-vein kratom is especially dangerous to combine with meth since it is the most stimulating kratom strains. Red-vein kratom may be a better choice since it is less stimulating, and the sedative properties may counterbalance the stimulating high from meth. However, kratom should be avoided if you’re also taking methamphetamine or other powerful stimulants.


  1. Galbraith, N. (2015). The methamphetamine problem: Commentary on… Psychiatric morbidity and socio-occupational dysfunction in residents of a drug rehabilitation centre. BJPsych bulletin, 39(5), 218-220.
  2. Richards, J. R., & Laurin, E. G. (2021). Methamphetamine toxicity. StatPearls [Internet].
  3. Eastlack, S. C., Cornett, E. M., & Kaye, A. D. (2020). Kratom—Pharmacology, clinical implications, and outlook: a comprehensive review. Pain and therapy, 9(1), 55-69.