Drug Interactions, Kratom Guides

Can You Mix Kratom & Loratadine (Claritin)?

Loratadine (Claritin) is a common over-the-counter allergy medication. Many people use it to help manage seasonal and indoor allergies, whether it be for pollen, pets, or dust. 

Kratom doesn’t really act as an antihistamine (though some people claim it helps), but it’s popular for other health issues. 

Both carry minimal health risks, but together there is a chance of a drug interaction. Kratom can intensify loratadine’s sedating effects, though the risk is moderate. 

Last updated 5 months ago by Wade Paul

Can You Mix Kratom & Loratadine (Claritin)?

Does Kratom Interact With Loratadine (Claritin)?

Kratom has a moderate chance of interacting with loratadine (Claritin)

The main concern is that both kratom and loratadine are sedatives. The combined sedative action of both substances could be much stronger than you expect. 

Additionally, kratom and loratadine may compete with each other for metabolism — leading to a longer duration of effects for both substances. 

Liver enzymes are responsible for breaking down just about every chemical that enters the body (as well as some of our naturally produced chemicals or hormones). If two or more drugs require the same enzyme, it can cause metabolism to slow down — potentially leading to a buildup of the compound in the bloodstream. 

Loratadine is mainly metabolized by an enzyme called CYP3A4, although it also uses other enzymes too, such as CYP2D6, CYP1A1, and CYP2C19 [1]. Kratom also requires the use of CYP3A4 and CYP2D6 enzymes for metabolization [2] and will therefore compete with loratadine. 

Speak to your doctor before you add kratom and loratadine to your regular lineup of substances.       

Kratom & Antihistamine Interactions

Loratadine is classified as an antihistamine. It treats the symptoms of allergies and allergic rhinitis. 

Loratadine belongs to the H1 class of antihistamines and is a second-generation. These types of antihistamines have far less risk of causing sedation, though it can still happen. 

Kratom and other antihistamines will have similar interactions.

Other related antihistamines kratom will interact with include:

  • Desloratadine 
  • Cetirizine
  • Levocetirizine 
  • Azelastine
  • Fexofenadine

Is It Safe to Take Kratom With Loratadine (Claritin)?

There’s a moderate risk involved when taking kratom and loratadine (Claritin) together. 

Kratom may increase the possible sedation that comes with loratadine. It’s best to speak to your doctor before mixing any medication with kratom.  

What Is Loratadine (Claritin)?

Loratadine (Claritin) was patented in 1980 and came to the market eight years later. The World Health Organization considers it an essential medicine. 

Loratadine can be found as an over-the-counter medication in the U.S., and it’s also the 66th most prescribed drug in the country. More than 11 million Americans have a prescription for loratadine. 

Loratadine Specs

Trade NameClaritin, Alavert 
CYP MetabolismCYP3A4
Interaction with KratomAgonistic interaction 
Risk of InteractionModerate

What Is Loratadine Used For?

Loratadine is used to treat allergies and allergic rhinitis. It’s sold over the counter without the need for a prescription. 

Some people take loratadine with kratom on purpose to potentiate its effects (make the effects of kratom last longer).     

What Are the Side Effects of Loratadine?

Loratadine (Claritin) is generally well-tolerated when taken on its own. However, you should be aware that there are some potential side effects.  

Common side effects of loratadine may include: 

  • Headache
  • Dry mouth
  • Diarrhea
  • Stomach pain
  • Sedation
  • Dizziness
  • Nausea & vomiting

What Is Kratom?

Kratom hails from Southeast Asia, where it has been used for centuries to boost energy. It’s a member of the coffee family and has had cultural significance throughout Southeast Asia since at least the 19th century. 

It has a myriad of health benefits, depending on the strain and amount used. 

What’s Kratom Used for?

Kratom is used for medicinal and recreational benefits. There have been some studies conducted on kratom, and it has been suggested that this substance may offer several benefits.  

Suggested health benefits of kratom include: 

What’s the Dose of Kratom?

Those who are new to taking kratom should stay on the low-dose side. It’s smart to start with 2 grams and go from there. The effects you want also determine how much kratom to take.

General dosage guidelines for kratom include: 

  • Low-Dose Kratom (2–6 gm)
  • High-Dose Kratom (6–12 gm)

Kratom is generally well-tolerated and doesn’t cause a lot of issues. However, for people who take more than a high dose of kratom (12+ gm), it may become a problem. 

Some users become addicted and can go through withdrawal symptoms. If you use kratom responsibly, this shouldn’t happen to you.  

What Are the Side Effects of Kratom?

Even with kratom being generally well-tolerated, there is still a risk of some side effects. Adverse effects are more common in higher doses.

Common side effects of kratom include: 

  • Nausea
  • Vomiting 
  • Sedation 
  • Lethargy 
  • Constipation 
  • Dizziness 
  • Anxiety
  • Brain fog 
  • Cognitive impairment 

What Are the Different Types of Kratom?

Kratom comes in many different strains. The strains are divided into four main colors for easy categorization: white, red, green, and yellow.

Each strain has its own benefits. There are many similarities for each class, though. 

Here’s a quick run-down of the different kratom strain colors

  1. White Vein Kratom: Best for energy, focus, and concentration. Effects are euphoric and energizing. 
  2. Red Vein Kratom: Best for sleep and pain, powerful and fast-acting. Effects are numbing and relaxing. 
  3. Green Vein Kratom: Balanced between white and red (sedating and stimulating).
  4. Yellow Vein Kratom: Made from a combination of white kratom and other strains. Effects cover all ranges of the spectrum (sedating or stimulating). 

Key Takeaways: Is It Safe to Mix Kratom & Loratadine (Claritin)?

Kratom is not usually known to have antihistamine properties, but it can cause sedation. Loratadine can also cause sedation. Mixing these two has a moderate risk because of this. If you want to use both medications, avoid using them together. 

If you’re taking loratadine and would like to add kratom into the mix, speak with your physician first. 


  1. Ghosal, A., Gupta, S., Ramanathan, R., Yuan, Y., Lu, X., Su, A. D. I., … & Alton, K. B. (2009). Metabolism of loratadine and further characterization of its in vitro metabolites. Drug metabolism letters, 3(3), 162-170.
  2. Kamble, S. H., Sharma, A., King, T. I., León, F., McCurdy, C. R., & Avery, B. A. (2019). Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica, 49(11), 1279-1288.