Drug Interactions, Kratom Guides

Is It Safe to Mix Kratom & Quetiapine (Seroquel)?

Quetiapine is an antipsychotic medication used to treat symptoms of schizophrenia, manic depressive (bipolar) disorder, major depressive disorder, and other mental health issues. 

It’s considered a metabolic competitor of kratom, so taking these drugs simultaneously can be dangerous and should be avoided at all costs.

In this article, you’ll learn how quetiapine interacts with kratom in the body and why they can be so dangerous when consumed together. You’ll also learn what quetiapine and kratom are used for and some of the side effects of each.

Last updated 5 months ago by Dr. Devin Carlson

Is It Safe to Mix Kratom & Quetiapine (Seroquel)?

Does Kratom Interact With Quetiapine (Seroquel)?

Quetiapine (Seroquel)  and kratom are metabolized by the same enzymes. As such, these two compounds are considered metabolic competitors.

Specifically, quetiapine and kratom are both metabolized by the enzyme CYP3A4 [1,3]. This leads both substances to experience a longer half-life as the liver struggles to keep up with metabolizing both efficiently. 

Without sufficient levels of activity from CYP3A4, dangerous levels of quetiapine can build up in the bloodstream. Unfortunately, overdoses of quetiapine can be fatal [2].

Since quetiapine is usually prescribed for daily use, levels of the drug can continue to rise in the bloodstream if this combination is used on a daily basis. 

It’s possible your doctor could recommend a lower dose of quetiapine if you plan to take kratom alongside it. Still, most physicians will very likely recommend ceasing kratom use altogether if they prescribe quetiapine.

Kratom & Antipsychotic Medication Interactions

Quetiapine is classified as an antipsychotic drug and is most often used for treating bipolar disorder, schizophrenia, and other mental health issues. 

Using other antipsychotic medications with kratom can bring a similar risk of negative interactions and is potentially dangerous.

Other related antipsychotic medications kratom will interact with include:

  • Aripiprazole (Abilify, Abilify Maintena & Aristada)
  • Asenapine (Saphris, Sycrest & Secuado)
  • Cariprazine (Vraylar & Reagila)
  • Chlorpromazine (Ormazine, Thorazine & Thorazine Spansule)
  • Clozapine (Clozaril, Fazaclo & Versacloz)
  • Fluphenazine (Moderate, Moderate Concentrate, Moditen, Prolixin & RhoFluphenazine)
  • Haloperidol (Haldol, Haldol Decanoate, Haloperidol LA & Peridol)
  • Lurasidone (Latuda)
  • Olanzapine (Zyprexa & Zyprexa Zydis)
  • Perphenazine (Trilafon, Etrafon, Triavil & Triptafen)
  • Risperidone (Risperdal M-Tab & RisperiDONE M-TAB)
  • Thioridazine (Mellaril)
  • Thiothixene (Navane)
  • Trifluoperazine (Stelazine)
  • Ziprasidone (Geodon, Zeldox & Zipwell)

Is It Safe to Take Kratom With Quetiapine (Seroquel)?

Most experts consider it unsafe to consume kratom while taking quetiapine (Seroquel). A physician may suggest a smaller dose of quetiapine that might be safe to take alongside kratom in some rare cases. 

However, most doctors will very strongly recommend against taking these two drugs together for any reason. The risk of dangerous and fatal interactions is relatively high.

What Is Quetiapine (Seroquel)?

Quetiapine (Seroquel) is an atypical antipsychotic medication used most commonly to treat schizophrenia, bipolar disorder, and other mental health issues.

Quetiapine Details & Specifications

Drug NameQuetiapine
Trade NameSeroquel & Seroquel XR
ClassificationAtypical Antipsychotic
CYP MetabolismCytochrome P450 (CYP3A4)
Interaction With KratomMetabolic Competitor
Risk of InteractionHigh

What Is Quetiapine (Seroquel) Used for?

Quetiapine is used most often to treat schizophrenia in young adults and adults. However, it has a variety of uses for treating other mental health disorders, including manic depressive disorder, major depressive disorder, and depression.

It’s considered one of the safest antipsychotics for young adults older than 13 years, making it one of the most prescribed substances for patients in this age range [4]. It’s also helpful in treating mental disorders in adults, but it can be hazardous for older patients coping with dementia.

What’s the Dose of Quetiapine (Seroquel)?

Quetiapine (Seroquel) is usually started in small doses of 25 mg twice per day for one to two days, after which the amount gradually increases to between 300 and 400 mg within a week. Standard tablets deliver between 25 and 200 mg, so quetiapine is typically taken twice per day.

Slow-release quetiapine tablets can contain up to 400 mg of the antipsychotic, allowing the patient to take a single dose each day.

Daily doses up to around 750 mg are considered safe and might be prescribed depending on symptoms and experienced side effects.

Most tablets are recommended to be taken on an empty stomach or with a light meal.

Generic & Brand Name Versions

Quetiapine is a generic drug name typically sold under the trade names Seroquel and Seroquel XR, the latter of which is the extended-release version.

There are a variety of other antipsychotic drugs that are similar in their effects: 

  • Aripiprazole
  • Asenapine
  • Cariprazine
  • Chlorpromazine
  • Clozapine
  • Fluphenazine
  • Haloperidol
  • Lurasidone
  • Olanzapine
  • Perphenazine
  • Risperidone
  • Thioridazine
  • Thiothixene
  • Trifluoperazine
  • Ziprasidone

What Are the Side Effects of Quetiapine (Seroquel)?

Quetiapine (Seroquel) can cause many different side effects; some are serious. 

Quetiapine’s more common side effects include:

  • Tiredness
  • Dizziness
  • Lightheadedness
  • Lethargy
  • Racing heartbeat
  • Congestion
  • Weight gain
  • Excessive hunger
  • Vomiting
  • Upset stomach
  • Constipation
  • Dry Mouth
  • Motor function issues

Some of the more severe side effects warrant an immediate call to your doctor. 

Quetiapine’s serious side effects include:

  • Involuntary muscle movements like chewing the lip 
  • Difficulty swallowing or speaking normally
  • Severe constipation
  • Continuous vomiting
  • Pain while urinating
  • Visual hallucinations, including tunnel vision
  • Stiff muscles
  • Fever
  • Chills
  • High blood pressure
  • Difficulty breathing
  • Fainting
  • Excessive thirst
  • Erratic heartbeat 

What Is Kratom?

Kratom is a ground-up form of the leaves from the Mitragyna speciosa tree, which grows primarily in Southeast Asia. It has been a popular treatment in traditional medicine for many centuries and can treat various symptoms.

What’s Kratom Used for?

Some of the most common uses of kratom include pain relief, sedation, relaxation, anxiety relief, enhancing mood, insomnia, boosting focus, and treating low energy or lack of motivation [5].

What’s the Dose of Kratom?

Most users take between 2 and 8 grams of kratom per day, but the specific dose within that range can vary quite a bit. Unlike most other drugs, kratom can have different effects based on the dose.

At low doses (between 1 and 4 grams), most users will experience stimulation, increased energy, and improved focus and concentration. Higher doses (between 4 and 8 grams) usually provide more powerful pain relief and intense sedation and relaxation.

It’s better to stay under 8 g of kratom powder per day, as higher doses tend to come with a greater risk of side effects.

Related: Can You Overdose on Kratom?

What Are the Side Effects of Kratom?

Kratom can come with several side effects, most of which aren’t severe for most users. The most common side effects of kratom use include nausea, upset stomach, dizziness, and lightheadedness.

Some users experience lethargy or anxiety, depending on the strain and dose they take daily.

One of the more severe side effects is dependence. Kratom can be habit-forming, so limiting your dose and taking week-long breaks once a month will often help reduce the risk of addiction.

What Are the Different Types of Kratom?

Kratom comes in three primary strain colors: red, green, and white. 

The effects of the kratom you consume tend to depend on the strain color.

A. White-Vein Kratom

White-vein kratom is more stimulating and often has nootropic effects, so many people take it to improve mental performance and boost energy. The alkaloid content responsible for white kratom’s effects is achieved by harvesting the kratom tree’s leaves early on in its maturation process.

B. Red-Vein Kratom

Red-vein kratom is most often used for pain relief and sedation, and many users take it as a sleep aid or to cure insomnia or restlessness. Farmers who want a red-vein variety tend to wait until the plant is fully mature to harvest the leaves.

C. Green-Vein Kratom

Green-vein kratom tends to be a hybrid of red and white, offering some of the benefits of each. Unsurprisingly, green-vein kratom is harvested in the middle of the tree’s maturation process, between when white and red-vein kratom would be harvested.

D. Yellow-Vein Kratom

Yellow-vein kratom is far less popular than the three primary color variations, and we don’t know much about how it’s produced. Some people speculate that the yellow color comes from the fermentation of the leaves after harvesting. Others maintain that the timing of the harvest is responsible for the unique color. Another theory is that the color comes from mixing red, white, and green varieties.

Key Takeaways: Is It Safe to Mix Kratom & Quetiapine (Seroquel)?

Quetiapine (Seroquel) is an atypical antipsychotic medication used to treat various mental disorders, including schizophrenia and bipolar disorder. It’s often taken daily to treat or prevent psychotic episodes.

It is unsafe to mix quetiapine and kratom, which is strongly recommended against by most doctors. These two substances are metabolic competitors of one another, so levels of both substances can build up in the bloodstream to dangerous or even toxic levels.

Some doctors might recommend a lower dose of quetiapine if you’re dead-set on taking kratom — however, generally speaking, you should avoid taking these two substances simultaneously.

References

  1. Bakken, G. V., Rudberg, I., Christensen, H., Molden, E., Refsum, H., & Hermann, M. (2009). Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug metabolism and disposition, 37(2), 254-258.
  2. Maan, J. S., Ershadi, M., Khan, I., & Saadabadi, A. (2017). Quetiapine.
  3. Kamble, S. H., Sharma, A., King, T. I., León, F., McCurdy, C. R., & Avery, B. A. (2019). Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica, 49(11), 1279-1288.
  4. Solmi, M., Murru, A., Pacchiarotti, I., Undurraga, J., Veronese, N., Fornaro, M., … & Carvalho, A. F. (2017). Safety, tolerability, and risks associated with first-and second-generation antipsychotics: a state-of-the-art clinical review. Therapeutics and clinical risk management, 13, 757.
  5. Eastlack, S. C., Cornett, E. M., & Kaye, A. D. (2020). Kratom—Pharmacology, clinical implications, and outlook: a comprehensive review. Pain and Therapy, 9(1), 55-69.