Drug Interactions, Kratom Guides

A Concise Guide To Combining Mirodenafil & Kratom

Individually, mirodenafil and kratom are relatively safe compounds, so it’s easy to assume their interaction is nothing to worry about. This is not quite true.

There is a certain interaction between these two compounds that is important to consider. Plus, you should always be aware of the risks involved in the use of kratom and mirodenafil by themselves. 

Last updated 5 months ago by Dr. Devin Carlson

A Concise Guide To Combining Mirodenafil & Kratom

Does Kratom Interact With Mirodenafil?

Yes, kratom and PDE5 inhibitors like mirodenafil can interact with each other. 

Mirodenafil is mainly metabolized by the CYP3A4 enzyme — which means that any compound that inhibits the activity of CYP3A4 will slow down the metabolization of mirodenafil.

Kratom is a CYP3A4 inhibitor, so using these two together can cause a buildup of mirodenafil and increase the risk of adverse reactions [1]. The likelihood of this resulting in any major issues is low but not impossible. People sensitive to Mirodenafil, kratom, or those who have preexisting heart conditions should avoid this combination. 

Talk to your doctor about the safety of this combination.

Is it Safe to Take Kratom With Mirodenafil?

There is a certain level of risk to consider because kratom inhibits mirodenafil’s metabolization.

This interaction leads to higher levels of mirodenafil within the body, translating into an increased rate of adverse effects.

However, if the dosage of mirodenafil is properly adjusted to reflect this interaction, there’s less risk. Only a doctor can adjust prescriptions and tell you for sure if this interaction is safe or not.  

What is Mirodenafil?

Mirodenafil — commercialized in Korea under the brand name Mvix — is a PDE5 inhibitor used to treat erectile dysfunction (ED).

As a PDE5 inhibitor, mirodenafil shares much of the same chemical structure and pharmacological profile as other medications in the class. PED5 inhibitors work to stimulate blood flow to certain tissues and are generally considered the ‘first-line response’ in the treatment of ED.

Although several trials have been conducted, it is important to note that mirodenafil has not been approved for use in the United States by the FDA [2].

Mirondenafil Specs:

Drug Name Mirodenafil
Trade Name Mvix
Classification PDE5 Inhibitor
CYP MetabolismPrimarily metabolized by CYP3A4
Interaction With Kratom Metabolic inhibitor
Risk of InteractionModerate

What is Mirodenafil Used for?

Like other PDE5 inhibitors, mirodenafil treats the symptoms of ED. 

Research shows it is just as effective as other PED5 inhibitors such as sildenafil and vardenafil, but there are still not enough studies on its pharmacodynamics [3].

PED5 inhibitors vary in certain metrics, such as maximum drug concentration and drug half-life. They can also differ in others ways, like their interaction with fatty foods. 

Finally, it is important to note that PDE5 inhibitors do not cure ED, only treat the symptoms. 

What’s the Dose of Mirodenafil?

Mirodenafil does not appear to be available for consumption outside of South Korea, so the official information regarding its dosage is limited.

Double-blind scientific studies point to the safety and efficacy of once-daily administrations of 50 mg of mirodenafil [4].

As with other PDE5 inhibitors, the preferable course of action is to begin with a small dose 

(half a pill) and see how your body responds first. 

Consult with your doctor about what PDE5 inhibitor is right for you.

Generic & Brand Name Versions

Mirodenafil is available in South Korea under the trade name Mvix.

What Are the Side Effects of Mirodenafil?

Even though research is limited, it’s safe to assume that the side effects profile of mirodenafil is quite similar to that of other PDE5 inhibitors.

Here are the side effects that may stem from mirodenafil use [5]:

  • Flushing
  • Headache
  • Nasal congestion
  • Nasopharyngitis
  • Eye redness
  • Dyspepsia
  • Nausea
  • Dizziness
  • Arthralgia
  • Palpitation

All side effects are generally mild to moderate in nature. 

Additionally, as opposed to other PDE5 inhibitors, mirodenafil does not appear to be associated with back pain or myalgia. 

What is Kratom?

Kratom is an all-natural herbal product with powerful psychoactive and pharmacological properties.

It’s filled with alkaloids like mitragynine and 7-hydroxymitragynine, making it an incredible compound with a vast suite of effects.

There are many ways to take kratom, but kratom tea and capsules are the most popular. Just be sure to buy kratom from a trusted source to remove the risk of adulterants.

Kratom is just starting to become known in the western hemisphere, and it’s still unregulated in many places. Some places have even banned kratom, so make sure you know the laws in your state.

Suggested Reading: Is Kratom Legal? A State-by-State Analysis

What is Kratom Used for?

One of the most amazing things about kratom is how many different benefits it can produce.

We can group them roughly into two groups: the nootropic and stimulant benefits vs. the pharmacological ones.

In terms of nootropics, kratom is a powerful supplement. Much like coffee, it can provide mental and physical alertness and an overall energy boost. Many users report increased attention and creativity, but it also possesses euphoric properties.

Regarding its pharmacological benefits, kratom has powerful analgesic and anxiolytic (anti-anxiety) qualities. It’s safer than most prescription painkillers and antidepressants, which is why it’s becoming a popular option as people try to replace these compounds.

As if that weren’t enough, kratom also has many more specific uses. 

You can also use kratom for the following:

What’s the Dose of Kratom?

As you’ve just seen, kratom has an awesome spectrum of benefits.

If you want to control which effects you feel, you need to learn which dose causes them. Kratom is a spectrum drug: its effects vary depending on the amount consumed. You’ll have to experiment to find out what works for you, but there are general dosing guidelines to get you started. 

Here are the average suggested doses:

  • Low dose (1 – 5 g): for nootropic and energizing effects
  • Medium dose (5 – 10 g): for more pain relief, relaxation; less stimulating
  • High dose (10 – 15 g): highly sedating and potent pain relief

The one thing to remember is that these numbers are just averages. Don’t trust them completely if you’re just starting out.

It’s best to start with a dose of no more than 2 g and see how that affects you.

What Are the Side Effects of Kratom?

Like all drugs, kratom has its fair share of side effects. These tend to be minor, but it’s good to know what to expect. These usually occur if you take too much.

The most common side effects include:

  • Constipation
  • Dizziness
  • Insomnia
  • Nausea
  • Itchiness

Again, there are some more problematic side effects though these are rare and typically happen when you’ve taken too much for too long. 

More serious side effects include:

  • Loss of muscle coordination
  • Low blood pressure
  • Low libido
  • Poor appetite
  • Seizures
  • Tremors

Another thing to be aware of: kratom is addictive

Kratom addiction is far less severe and less likely compared to pharmacological drugs like antidepressants or painkillers, but it’s always a possibility. 

Make sure to become familiar with the dangers of kratom use

What Are the Different Types of Kratom?

Kratom comes in a number of different strains.

These strains are all named after the color of the leaf’s vein. However, once they’re processed, they all look the same.

These strains all have roughly the same effects, but slight differences in the alkaloid profile give them particular characteristics.

A) White Vein Kratom

White-veined strains help you get the most out of the nootropic, energizing benefits of the kratom plant.

These excel at boosting focus and energy and are generally uplifting. They’re very popular with people who want to replace their morning coffee or need to power through the day.

B) Red Vein Kratom

Red-veined strains excel at producing the pharmacological properties of kratom — the benefits that come with higher doses.

This is an excellent choice for those who want to treat their chronic pain or anxiety but do not want to consume quite so much kratom.

C) Green Vein Kratom

Green vein kratom strains aren’t like red or white. They don’t produce a targeted experience but instead give the whole swathe of benefits that kratom can offer, but less extreme.

D) Yellow Vein Kratom

The kratom community thinks yellow-vein kratom is pretty much the same as green except milder. Those with a sensitivity to kratom and first-timers tend to gravitate to it.

Key Takeaways: Is it Safe to Mix Kratom & Mirodenafil?

Mirodenafil and kratom both carry some risks. Kratom can slow down mirodenafil’s metabolization and increase the risk of adverse reactions.

In reality, the danger is quite minimal if you take them correctly. Still, talk to your doctor since they’re the only ones qualified to make the decision.

References

  1. Hanapi, N. A., Ismail, S., & Mansor, S. M. (2013). Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities. Pharmacognosy research, 5(4), 241.
  2. Dhaliwal, A., & Gupta, M. (2021). PDE5 inhibitors. StatPearls [Internet].
  3. Park, H. J., Moon, K. H., Lee, S. W., Lee, W. K., Kam, S. C., Lee, J. H., & Park, N. C. (2014). Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. The World Journal of men’s health, 32(1), 18-27.
  4. Chung, J. H., Kang, D. H., Oh, C. Y., Chung, J. M., Lee, K. S., Kim, T. H., … & Lee, S. W. (2013). Safety and efficacy of once-daily administration of 50 mg mirodenafil in patients with erectile dysfunction: a multicenter, double-blind, placebo controlled trial. The Journal of urology, 189(3), 1006-1013.
  5. Cho, M. C., & Paick, J. S. (2016). A review of the efficacy and safety of mirodenafil in the management of erectile dysfunction. Therapeutic advances in urology, 8(2), 100-117.