Drug Interactions, Kratom Guides

Is It Safe To Mix Kratom & Testosterone?

Testosterone treatments are most often prescribed long-term, so it’s important to understand how this prescription may affect your kratom use.

In general, kratom and testosterone are unlikely to interact directly, but you may face a higher risk of experiencing side effects from either substance. 

Here, we’ll explore how kratom and testosterone may interact when used together and what you can do to stay safe and reduce your chances of experiencing side effects. 

Medically reviewed by Dr. Devin Carlson

Last updated 5 months ago by Wade Paul

Is It Safe To Mix Kratom & Testosterone?

Does Kratom Interact With Testosterone?

In short, no — there does not appear to be any meaningful interactions between testosterone and kratom [1]. 

However, studies show that kratom may increase prolactin, which can indirectly lead to a decrease in testosterone levels [2]. While there’s no official evidence this effect has any negative impacts on testosterone, it’s something you’ll need to consider. Depending on what’s deemed to be the “cause” of your low testosterone, taking kratom may only serve to worsen the problem. 

If you’re taking testosterone for any reason, you should speak with your doctor before taking any kratom. 

Related: Will Kratom Interact With My Medications?

Testosterone Specs Chart

Drug Name Testosterone
Trade Name Aveed, Depo-testosterone, Delatestryl, Testopel, Andro-gel, Testim, TestoGel, Andriol, Androderm, Depo-Testosterone, Intrinsa, Bebido, Omnadren, Primoteston, Sustanon, TestoPatch, Testoviron, Tostran, etc.
Classification Steroid
MetabolismTestosterone is metabolized in the liver mainly by reduction and conjugation
Interaction With Kratom No known effect
Risk of InteractionLow

Is it Safe to Take Kratom With Testosterone?

Yes, but with caution and professional oversight. 

Adverse reactions aren’t expected between kratom and testosterone under normal conditions. Certain health conditions, such as hyperprolactinemia, may carry an increased risk of side effects. 

What is Testosterone?

Testosterone is the male sex hormone. It’s made in the testicles and, to a lower extent, the ovaries. Technically, it’s classified as a steroid. 

Testosterone is crucial for many processes related to male sexual development and functions. For example, it’s responsible for driving the development of body and facial hair, as well as the creation of sperm.

This hormone is also largely responsible for the lower tone of voice and increased muscle and bone mass associated with the male sex.

Testosterone production in the body increases naturally for males at the start of puberty. Research shows that around 40 years of age, it begins decreasing naturally at a rate of around 1-2% per year. 

External factors, such as exposure to synthetic hormones, poor diet, lack of exercise, radiation, and heavy metals, can all lead to more rapid testosterone loss starting around the age of 30. 

Unusually low levels of testosterone in males can lead to a whole host of negative symptoms such as decreased sex drive, infertility, depressive moods, etc.

What is Testosterone Used for?

Apart from its functions as a naturally occurring hormone, testosterone is used to treat a number of conditions.

Hypogonadism is the decreased production of sex hormones; in men, it leads to decreased levels of testosterone. Synthetic testosterone is often used to treat this condition which often gets worse with age [3]. This is known as testosterone replacement therapy (TRT).

Testosterone also has therapeutic uses in the treatment of certain types of breast cancer [4]. 

Some doctors will also prescribe testosterone as a treatment for gender dysphoria [5].

Testosterone is sometimes used for the purpose of improving athletic ability (called doping). This use is almost always banned in professional athletic competitions. The World Anti-Doping Agency (WADA) lists testosterone as a substance that is “prohibited at all times.”

What’s the Dose of Testosterone?

The proper dosage of testosterone is not something that can be figured out by browsing the internet — it depends on factors including weight, current testosterone status, age, medication use, and much more. 

Any form of treatment involving testosterone needs to be initiated with the diagnosis of a licensed doctor.

There are a vast number of complicating factors, and determining the proper dosage of testosterone can only be done by a physician. Also, there is usually a fair amount of laboratory testing that needs to happen to establish your baseline levels.

Once you have properly consulted with a doctor, take your testosterone according to the specifics you’ve been given.

Testosterone can be applied as a gel, skin patch, oral tablet, as well as through muscular injection.

Generic & Brand Name Versions

Testosterone is available under the following brand names:

  • Aveed 
  • Depo-testosterone
  • Delatestryl
  • Testopel
  • Andro-gel
  • Testim
  • TestoGel
  • Andriol
  • Androderm
  • Depo-Testosterone
  • Intrinsa
  • Bebido
  • Omnadren
  • Primoteston
  • Sustanon
  • TestoPatch
  • Testoviron
  • Tostran

What Are the Side Effects of Testosterone

There are a lot of side effects associated with testosterone therapy. The side effects will be different in men than in women and depend on the individual. 

Contraindications to taking testosterone are:

  • Male breast cancer
  • Prostate cancer
  • Serious heart problems
  • Severe liver disease
  • Severe kidney disease
  • Pregnancy

Minor side effects of testosterone might include [6]:

  • Oily skin
  • Acne
  • Seborrhea
  • Hair loss
  • Excessive hair growth (in women)
  • Deepening of the voice

More serious adverse effects are [7]:

  • Spermatogenesis
  • Gynecomastia
  • Mood swings
  • Increased aggression
  • Spontaneous erections
  • Increased hematocrit
  • Increased risk of cardiovascular events

What is Kratom?

Kratom is made from the leaves of a tropical evergreen tree that is native to Southeast Asia called Mytragana speciosa.

Kratom, like coffee, derives its psychoactive properties from the naturally occurring alkaloids within it. In fact, kratom is a member of the coffee family of plants. 

Inside the body, kratom behaves very similarly to an opiate — this is the main reason the FDA has been concerned about kratom. It interacts with the opioid receptors in the central nervous system (CNS).

Kratom can be enjoyed in many different preparations. Try a kratom tea or go for kratom capsules if you don’t like the bitter taste. 

What is Kratom Used for?

Kratom’s many properties have led to many different uses for the plant.

Even though few scientific studies can confirm these effects, the kratom community is filled with people who will attest to kratom’s benefits. Existing studies show it has plenty of therapeutic potentials.

In low doses, kratom acts as a nootropic and can increase overall mental vitality, leading to increased focus and creativity. Kratom can also serve to improve mood.

As kratom dosage increases, the effects begin to slide over into another area of the kratom spectrum. 

In these ranges, kratom has analgesic properties and can help reduce anxiety. These benefits have made kratom quite popular with those who want an herbal option instead of a pharmacological one.

As if these qualities weren’t enough, kratom eases opiate withdrawal symptoms and might be effective as a weight-loss supplement

What’s the Dose of Kratom?

As we have seen, the effects of kratom are highly dependent on the dosage. It’s important to remember this if you want to be in control of your kratom experience. 

The standard kratom dosages are:

  • Low dose (1 – 5 g)
  • Medium dose (5 – 10 g)
  • High dose (10 – 15 g)

As always, remember that dosage recommendations are just averages. Formulaic dosage prescriptions can never account for all the different factors influencing proper dosage.

If it’s your first time with kratom, make sure to start with a low dose, less than 3 g, and see how your body reacts to the compound. 

What Are the Side Effects of Kratom?

Kratom may cause the following side effects:

  • Constipation
  • Dizziness
  • Insomnia
  • Nausea

More serious side effects include:

  • Itchiness 
  • Loss of muscle coordination
  • Low blood pressure
  • Low libido
  • Nausea
  • Poor appetite
  • Seizures
  • Tremors

Additionally, kratom can be addictive, causing symptoms of mental and physical dependence.

Suggested Reading: Is Kratom Dangerous?

What Are the Different Types of Kratom?

Kratom is available in four different types of strains. The four kratom strains all have similar effects. However, they do differ in the sense that each kratom strain emphasizes certain aspects.

The strains are all named after the color of the leaf’s vein — once they’re processed, they all look exactly the same.

Become familiar with the four types of strain, and you can tweak your kratom experience so it’s just right.

A) White Vein Kratom

White vein kratom is known to excel at promoting the effects that are typically associated with a lower dose of kratom: the nootropic, stimulant effects.

White vein is popular with early-risers who want to replace their morning coffee and with those who have creative jobs.

B) Red Vein Kratom

Red-veined kratom could be thought of as being ‘opposite’ to white vein strains. This is because they’re best used if one wants to feel the effects of a higher dose of kratom.

Red vein kratom is the best option to produce the anxiolytic and analgesic properties of kratom. Those who suffer from chronic pain and anxiety usually gravitate towards this strain.

C) Green Vein Kratom

Green vein kratom is conceptualized in the kratom community as the ‘middle-point’ between red and white kratom strains. Green-veined strains combine the properties of both in order to provide a generalized experience.

If you’d prefer to experience everything kratom has to offer, then go with a green vein kratom strain.

D) Yellow Vein Kratom

Yellow vein kratom does not possess any remarkable characteristics. The only thing that sets it apart is that it’s the mildest out of all of them. This makes yellow vein the natural choice for those who have a sensitivity to kratom.

Key Takeaways: Is it Safe to Mix Kratom & Testosterone?

Kratom and testosterone should be safe to mix but always talk to your doctor first.

This, of course, does not mean that you do not have to worry at all. Both kratom and testosterone do carry certain risks by themselves, and these will always be present.

The good news is that kratom’s adverse effects are usually mild and can be brought down to manageable levels by simply cutting back on consumption.

References

  1. Singh, D., Murugaiyah, V., Hamid, S. B. S., Kasinather, V., Chan, M. S. A., Ho, E. T. W., … & Mansor, S. M. (2018). Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users. Journal of ethnopharmacology, 221, 30-36.
  2. LaBryer, L., Sharma, R., Chaudhari, K. S., Talsania, M., & Scofield, R. H. (2018). Kratom, an emerging drug of abuse, raises prolactin and causes secondary hypogonadism: case report. Journal of investigative medicine high impact case reports, 6, 2324709618765022.
  3. Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., … & Yialamas, M. A. (2018). Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 103(5), 1715-1744.
  4. Boni, C., Pagano, M., Panebianco, M., Bologna, A., Sierra, N. M. A., Gnoni, R., … & Bisagni, G. (2014). Therapeutic activity of testosterone in metastatic breast cancer. Anticancer Research, 34(3), 1287-1290.
  5. Costa, L. B. F., Rosa-e-Silva, A. C. J. D. S., Medeiros, S. F. D., Nacul, A. P., Carvalho, B. R. D., Benetti-Pinto, C. L., … & Maranhão, T. M. D. O. (2018). Recommendations for the use of testostero
  6. Grech, A., Breck, J., & Heidelbaugh, J. (2014). Adverse effects of testosterone replacement therapy: an update on the evidence and controversy. Therapeutic advances in drug safety, 5(5), 190-200.
  7. Finkle, W. D., Greenland, S., Ridgeway, G. K., Adams, J. L., Frasco, M. A., Cook, M. B., … & Hoover, R. N. (2014). Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men. PloS one, 9(1), e85805.