Drug Interactions, Kratom Guides

Kratom & Udenafil (Zydena): What Happens if They’re Combined?

One might think that a herbal psychoactive compound such as kratom would have little interaction with udenafil — a drug meant to treat erectile dysfunction.

Nevertheless, drug interactions are complex things, and you might be surprised. It’s for this reason that you should always do a little research.

Thankfully, if you’re wondering what the interaction between kratom and udenafil might look like, we’ve got you covered.

Medically reviewed by Dr. Devin Carlson

Last updated 5 months ago by Wade Paul

Kratom & Udenafil (Zydena): What Happens if They’re Combined?

Does Kratom Interact With Udenafil (Zydena)?

There’s a low to medium risk with mixing kratom and PDE5 inhibitors like udenafil. These drugs treat erectile dysfunction and possess no psychoactive properties.

On the other hand, kratom has a vast suite of psychoactive and medical benefits.

These two do not have similar physical effects, but they do have overlap in the area of metabolization. Udenafil is mainly metabolized by cytochrome CYP3A4. This is significant, as kratom is a potent CYP3A4 inhibitor [1].

Kratom can slow down udenfil’s metabolization, causing a potentially problematic drug interaction. PDE5 inhibitors enhance the ability of arteries; slowed metabolization can lead to an increased amount of udenafil and could cause damage to the arterial system.

Udenafil Specs

Drug NameUdenafil
Trade NameZydena
ClassificationPDE5 Inhibitor
CYP MetabolismPrimarily metabolized by CYP3A4, with contributions from CYP3A5
Interaction With KratomKratom inhibits udenafil’s metabolization
Risk of InteractionLow

Is it Safe to Take Kratom With Udenafil (Zydena)?

 While the risk is relatively low, there’s still the potential for an adverse reaction. It’s best to avoid mixing these two unless you talk to your doctor first.

Kratom’s inhibitory effect can mean that udenafil takes longer to clear from the body. If you’re taking the drug daily, this could cause a slow but constant buildup of udenafil.

This accumulation increases the risk of adverse effects and may cause toxicity. Be sure to talk to your doctor, and limit your kratom intake if you’re using udenafil daily.

What is Udenafil?

 Udenafil — sold under the trade name Zydena — is used to treat erectile dysfunction. Like other drugs used to treat this condition, the compound is classified as a PDE5 inhibitor.

Udenafil is fast-acting; peak plasma concentrations in the bloodstream peak in 1 to 1.5 hours. Additionally, it also has a long half-life of 11 to 13 hours.

It is important to note that udenafil is not yet FDA-approved in the United States, although phase II trials are underway. Udenafil is available in Korea, Russia, and the Philippines.

What is Udenafil Used for?

Udenafil is used to treat erectile dysfunction.

The pharmacokinetics of udenafil allows users to take a once-daily dosage at a time of their choosing [2].

It can also be taken on-demand. However, couples often find that taking the drug on-demand reduces sexual spontaneity.

Currently, the only daily-dose, FDA-approved treatment for erectile dysfunction is tadalafil (Cialis). This is problematic for some who cannot tolerate the drug due to phosphodiesterase subtype selectivity.

At the moment, there are four other PDE5 inhibitors used to treat erectile dysfunction: sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis), and avanafil (Stendra).

If you’re looking to treat your erectile dysfunction, be sure to consult with your physician to determine what will work best for your sexual habits and preferences.

What’s the Dose of Udenafil?

The appropriate dosage of udenafil will always depend on the patient.

Udenafil doses range from 50 mg to 100 mg or even 200 mg, depending on their dosing regimen (daily or on-demand) and what works best for the individual.

One study found that udenafil improved ED symptoms when administered in doses of 50 mg or 75 mg daily for twelve weeks [3].

We must also remember that udenafil is still undergoing clinical trials in the US. If you’re planning on using udenafil, be sure to consult your doctor on what dosage is appropriate for you.

Generic & Brand Name Versions

Udenafil was developed by Dong-A Pharmaceutical and is sold under the trade name Zydena.

What Are the Side Effects of Udenafil

Studies show the main adverse effects resulting from udenafil were headaches and flushing. Thankfully, these were classified as transient and mild [4].

The following side effects are also common:

  • Heartburn
  • Nausea
  • Coughing
  • Dizziness
  • Nasal congestion
  • Increased sensitivity to light
  • Diarrhea

What is Kratom?

Kratom (Mitragyna speciosa) is a herbal extract that contains a wide array of plant-based alkaloids.

Alkaloids are natural compounds in many types of living organisms. They can cause powerful reactions within the body.

The main alkaloids found in kratom are mitragynine and 7-hydroxymitragynine — these account for the many benefits that kratom provides.

Kratom is harvested from the leaves of the Mitragyna speciosa, a species of evergreen tree native to Southeast Asia.

Kratom comes in several different forms, from tinctures to powder, kratom consumption. Its popularity in the United States is snowballing.

What is Kratom Used for?

Kratom has many uses, but there are five main ones.

The most common uses for kratom are:

  1. Pain relief
  2. Opioid withdrawal
  3. Sleep aid
  4. Nootropic effects (focus, mood)
  5. Energy

When administered in low doses, kratom can stimulate the mind and produce valuable benefits. For instance, it can increase energy, like coffee only without the jitters. It can also create the opposite effect and promotes sleep (in larger doses).

It also has mood-enhancing properties, making it popular among those that deal with depression.

When it comes to the medical benefits, kratom doesn’t disappoint either. Kratom also has potent analgesic and anxiolytic (anti-anxiety) benefits.

As if that weren’t enough, kratom has shown promise as a weight-loss supplement and treating the symptoms stemming from withdrawal symptoms.

What’s the Dose of Kratom?

As with most other drugs, proper dosage recommendations vary according to several factors, such as total body mass and method of consumption. However, there are dose recommendations that act as a guide.

Standard kratom doses:

  • Low dose (1-5 g) — for stimulating and nootropic effects
  • Medium dose (5-10 g) — for analgesic and anxiolytic effects
  • High dose (10-15 g) — very potent; for sleep and pain relief; not recommended for inexperienced users.

If you’re new to kratom, it’s best to go slow and see how your body reacts. You might have a sensitivity to it. In any case, first-timers should never exceed 5 grams.

Related: How Long Should I Wait Between Kratom Doses?

What Are the Side Effects of Kratom?

There are a few side effects from kratom that most often come with higher doses. These are avoidable if you stick to smaller amounts, though some people may still experience them.

The side effects of kratom are:

  • Nausea
  • Insomnia
  • Lethargy
  • Dizziness

Other, less common, side effects include:

  • Hyperpigmentation
  • Low libido
  • Poor appetite
  • Loss of muscle coordination
  • Tremors or muscle contractions
  • Low blood pressure
  • Itchiness in the skin
  • Seizures

Thankfully, kratom’s side effects are mild.

If side effects become too pervasive, it’s time to scale back kratom consumption considerably.

Lastly, since kratom is unregulated, buying from untrustworthy kratom sellers can put you at risk of exposure to contaminants, one of the most significant risks of using kratom.

Always buy your kratom from a trustworthy source.

What Are the Different Types of Kratom?

A) White Vein Kratom

White vein kratom is a mind-based strain and excels at producing nootropic benefits. They’re the perfect way to add a punch to your morning.

B) Red Vein Kratom

The red-veined kratom strains are the go-to choice for people dealing with chronic pain or those who want to treat their anxiety but don’t want to resort to prescription medications.

Red vein kratom is an excellent choice for these two options as it is the most analgesic and anxiolytic type of strain, excellent for those who don’t want to consume too much kratom but want pain relief.

C) Green Vein Kratom

Green vein kratom sits right between white and red in the kratom spectrum.

They have a balanced alkaloid profile that contains both analgesic and anxiolytic properties and mind-based effects.

However, this means that you won’t experience the targeted nature of a white or red kratom strain.

D) Yellow Vein Kratom

Yellow vein kratom is the odd man out. It doesn’t really have any distinguishing characteristics except that it is usually considered a milder strain and similar to green strains.

If you happen to have a sensitivity to kratom, then the yellow-veined strains are your best option.

Key Takeaways: Is it Safe to Mix Kratom & Udenafil (Zydena)?

Simply said: it’s likely safe, but there’s still a chance there could be problems because of how these two are metabolized. It’s best to talk to your doctor before combining them.

If you take udenafil on-demand or in low doses, then there’s likely little to worry about. However, if you take udenafil daily, you will probably want to regulate your kratom consumption.

To be safe, alert your physician about this combination and always be sure to consume kratom in responsible dosages.


  1. Hanapi, N. A., Ismail, S., & Mansor, S. M. (2013). Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities. Pharmacognosy research, 5(4), 241.
  2. Kang, S. G., & Kim, J. J. (2013). Udenafil: efficacy and tolerability in the management of erectile dysfunction. Therapeutic advances in urology, 5(2), 101-110.
  3. Zhao, C., Kim, S. W., Yang, D. Y., Kim, J. J., Park, N. C., Lee, S. W., … & Park, J. K. (2011). Efficacy and safety of once-daily dosing of udenafil in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial. European urology, 60(2), 380-387.
  4. Paick, J. S., Kim, S. W., Park, Y. K., Hyun, J. S., Park, N. C., Lee, S. W., … & Chung, W. S. (2009). ED PHARMACOTHERAPY: The Efficacy and Safety of Udenafil [Zydena] for the Treatment of Erectile Dysfunction in Hypertensive Men Taking Concomitant Antihypertensive Agents. The journal of sexual medicine, 6(11), 3166-3176.