Does Kratom Interact With Mirodenafil?
Yes, kratom and PDE5 inhibitors like mirodenafil can interact with each other.
Mirodenafil is mainly metabolized in the liver by the CYP3A4 enzyme. This means that any compound that inhibits the activity of CYP3A4 will slow down mirodenafil’s metabolism [1].
Kratom is a CYP3A4 inhibitor, so using these two compounds together can cause a buildup of mirodenafil and increase the risk of adverse reactions [2].
It’s unlikely that this interaction will cause significant health issues, but not impossible. People sensitive to mirodenafil, kratom, or those with preexisting heart conditions should avoid this combination.
Talk to your doctor to get proper, individualized guidance about the safety of this combination.
Is it Safe to Take Kratom With Mirodenafil?
Not really. There is a certain level of risk to consider because kratom inhibits mirodenafil’s metabolization.
This metabolic inhibition leads to higher levels of mirodenafil within the body, translating into an increased rate of adverse effects.
However, if the dosage of mirodenafil is adequately adjusted to prevent this interaction, there’s less risk. However, only a doctor can adjust prescriptions and tell whether this interaction is safe.
What is Mirodenafil?
Mirodenafil — commercialized in Korea under the brand name Mvix — is a PDE5 inhibitor used to treat erectile dysfunction (ED).
As a PDE5 inhibitor, mirodenafil shares much of the same chemical structure and pharmacological profile as other medications in the class. PDE5 inhibitors stimulate blood flow to specific tissues and are generally considered the ‘first-line response’ in the treatment of ED.
Although several trials have been conducted, it is essential to note that mirodenafil has not been approved for use in the United States by the FDA [3].
Mirondenafil Specs
| Drug Name | Mirodenafil |
| Trade Name | Mvix |
| Classification | PDE5 Inhibitor |
| CYP Metabolism | CYP3A4 |
| Interaction With Kratom | Metabolic inhibition |
| Risk of Interaction | Moderate |
What is Mirodenafil Used for?
Like other PDE5 inhibitors, mirodenafil treats the symptoms of erectile dysfunction (ED).
Research shows it is just as effective as other PDE5 inhibitors, such as sildenafil and vardenafil, but there are still not enough studies on its pharmacodynamics [4].
PDE5 inhibitors vary in specific metrics, such as maximum drug concentration and half-life. They can also differ in other ways, like their interaction with fatty foods.
Finally, it is essential to note that PDE5 inhibitors do not cure ED; they only treat the symptoms.
What’s the Dose of Mirodenafil?
Mirodenafil is unavailable for consumption outside of South Korea, so the official information regarding its dosage is limited.
Double-blind scientific studies point to the safety and efficacy of once-daily administrations of 50 mg of mirodenafil [5].
As with other PDE5 inhibitors, starting a small dose (half a pill) and seeing how your body responds first is preferable.
Consult with your doctor about what PDE5 inhibitor is suitable for you.
Generic & Brand Name Versions
Mirodenafil is available in South Korea under the trade name Mvix.
What Are the Side Effects of Mirodenafil?
Even though research is limited, it’s safe to assume that the side effects profile of mirodenafil is quite similar to that of other PDE5 inhibitors.
Here are the side effects that may stem from mirodenafil use [6]:
- Arthralgia
- Dizziness
- Dyspepsia
- Eye redness
- Flushing
- Headache
- Nasal congestion
- Nasopharyngitis
- Nausea
- Palpitation
All side effects are generally mild to moderate in nature.
Additionally, as opposed to other PDE5 inhibitors, mirodenafil does not appear to be associated with back pain or myalgia (muscle pain).
What is Kratom?
Kratom is an all-natural herbal product with powerful psychoactive and pharmacological properties.
It’s filled with alkaloids like mitragynine and 7-hydroxymitragynine, making it an incredible compound with vast effects.
There are many ways to take kratom, but kratom tea and capsules are the most popular. Just be sure to buy kratom from a trusted source to remove the risk of adulterants.
Kratom is just starting to become known in the western hemisphere and is still unregulated in many places. Some countries have even banned kratom, so make sure you know the laws in your state.
Suggested Reading: Is Kratom Legal? A Global Analysis
What is Kratom Used for?
One of the most amazing things about kratom is its vast range of benefits.
We can roughly group the benefits into the nootropic/stimulant and the pharmacological.
In terms of nootropics, kratom is a powerful supplement. Like coffee, it can provide mental and physical alertness and an overall energy boost. Many users report increased attention and creativity when taking kratom, but it also possesses euphoric properties.
Regarding its pharmacological benefits, kratom has potent analgesic and anxiolytic (anti-anxiety) qualities. It’s safer than most prescription painkillers and antidepressants, which is why it’s becoming popular among people with chronic pain and anxiety-related conditions.
As if that weren’t enough, kratom has many more specific uses.
You can also use kratom for the following:
- Ease symptoms of opioid withdrawal
- Management of migraines
- Relieve symptoms of depression
- Sleep aid
- Weight-loss supplement
What’s the Dose of Kratom?
As you’ve just seen, kratom has an incredible spectrum of benefits.
To control your effects, you need to learn about the dosage range. Kratom is a spectrum drug: its effects vary depending on the amount consumed. You’ll have to experiment to find out what works for you, but there are general dosing guidelines to get you started.
Here are the average suggested doses:
- Low dose (1 – 5 g): for nootropic and energizing effects
- Medium dose (5 – 10 g): for more pain relief, relaxation, less stimulating
- High dose (10 – 15 g): highly sedating and potent pain relief
The one thing to remember is that these numbers are just averages. Don’t trust them entirely if you’re starting.
It’s best to start with a dose of no more than 2 g and see how that affects you.
What Are the Side Effects of Kratom?
Like all drugs, kratom has its fair share of side effects. These tend to be minor, but it’s good to know what to expect. These usually occur if you take too much.
The most common side effects include:
- Constipation
- Dizziness
- Headaches
- Heart palpitations
- Insomnia
- Itchiness
- Nausea
Again, there are some more problematic side effects though these are rare and typically happen when you’ve taken too much for too long.
More severe side effects include:
- Dependence and addiction
- Liver damage (with long-term use)
- Loss of muscle coordination
- Low blood pressure
- Low libido
- Poor appetite
- Seizures
- Tremors
Kratom addiction is far less severe and less likely than pharmacological drugs like antidepressants or painkillers, but it’s always possible. To ensure you’re safe, become familiar with the dangers of kratom use before taking it.
What Are the Different Types of Kratom?
When buying kratom, you’ll notice it is available in several strains.
These strains are all named after the color of the leaf’s vein. However, once they’re processed and ground, all kratom powders look the same, regardless of the strain.
Each strain has a different alkaloid profile with particular characteristics and effects. Let’s dive into the specifics of each kratom strain.
White Vein Kratom
White-veined strains help you get the most out of the nootropic, energizing benefits of the kratom plant.
These excel at boosting focus and energy and are generally uplifting. They’re very popular with people who want to replace their morning coffee or need power throughout the day.
Red Vein Kratom
Red-veined strains excel at producing the pharmacological properties of kratom — the benefits that come with higher doses.
This is an excellent choice for those who want to treat their chronic pain or anxiety but do not want to consume quite so much kratom.
Green Vein Kratom
Green vein kratom strains aren’t like red or white. They don’t produce a targeted experience but instead give the whole swathe of benefits that kratom can offer, but less extreme.
Yellow Vein Kratom
The kratom community thinks yellow-vein kratom is pretty much the same as green except milder. Those with a sensitivity to kratom and first-timers tend to gravitate to it.
Key Takeaways: Is it Safe to Mix Kratom & Mirodenafil?
Mirodenafil and kratom both carry some risks. Kratom can slow down mirodenafil’s metabolization and increase the risk of adverse reactions.
The danger is relatively minimal if you take them following a doctor’s prescription. Talk to your doctor to help you make an informed decision.
- Lee, H. S., Park, E. J., Ji, H. Y., Kim, S. Y., Im, G. J., Lee, S. M., & Jang, I. J. (2008). Identification of cytochrome P450 enzymes responsible for N-dealkylation of a new oral erectogenic, mirodenafil. Xenobiotica, 38(1), 21-33.
- Hanapi, N. A., Ismail, S., & Mansor, S. M. (2013). Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities. Pharmacognosy research, 5(4), 241.
- Dhaliwal, A., & Gupta, M. (2021). PDE5 inhibitors. StatPearls [Internet].
- Park, H. J., Moon, K. H., Lee, S. W., Lee, W. K., Kam, S. C., Lee, J. H., & Park, N. C. (2014). Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. The World Journal of men’s health, 32(1), 18-27.
- Chung, J. H., Kang, D. H., Oh, C. Y., Chung, J. M., Lee, K. S., Kim, T. H., … & Lee, S. W. (2013). Safety and efficacy of once-daily administration of 50 mg mirodenafil in patients with erectile dysfunction: a multicenter, double-blind, placebo controlled trial. The Journal of urology, 189(3), 1006-1013.
- Cho, M. C., & Paick, J. S. (2016). A review of the efficacy and safety of mirodenafil in the management of erectile dysfunction. Therapeutic advances in urology, 8(2), 100-117.
