Drug Interactions, Kratom Guides

Kratom and Quercetin: Are These Two Safe to Combine?

Quercetin is a pigment (flavonoid) found in many plants and foods (flavonoid), including red wine, onions, green tea, apples, and berries.

Quercetin has anti-inflammatory and antioxidant properties that may help reduce swelling, destroy cancer cells, regulate blood sugar, and prevent heart disease.

On consuming quercetin with kratom, an antagonistic interaction can occur. At high doses, kratom can raise blood pressure while quercetin decreases it. As a result of the medications’ opposing actions, blood pressure levels may rise, resulting in greater adverse effects. Quercetin may also affect kratom’s metabolism by interfering with the enzymes involved.

Last updated 4 months ago by Dr. Devin Carlson

Kratom and Quercetin: Are These Two Safe to Combine?

Does Kratom Interact With Quercetin (Quercetin Bromelain)?

Kratom can interact indirectly with quercetin and as a result of behaviors that are fundamentally opposed. Kratom can work against quercetin’s effects, causing a mild to moderate interaction.

Always with your prescribing physician before combining kratom and quercetin.

The interaction of kratom and quercetin can take two forms:

Kratom Can Decrease Quercetin’s Effects (Antagonistic Interaction)

Kratom and quercetin can interact antagonistically. 

While small doses of kratom may decrease blood pressure, long-term use may cause blood pressure to rise, posing significant health risks.

When two drugs with opposing effects on the body are combined, antagonistic interaction occurs. These drugs may act on the same or separate receptors, but when combined, they have different or opposing effects.

By elevating blood pressure, the stimulating effects of kratom may operate against the blood-pressure-lowering effects of quercetin.

Because both medications have opposing effects, taking them together can cancel out each other’s effects, raising blood pressure and causing more problems.

Quercetin’s Metabolization May Be Slowed Down (Metabolic Competitor)

There is a possible chance of metabolic interaction between quercetin and kratom. 

Kratom is metabolized by the cytochrome enzymes of the liver, namely CYP3A4, CYP2D6, and CYP2C9.

On the other hand, the same CYP enzymes that metabolize quercetin are unknown. However, it has been found to inhibit CYP2D6, CYP2C19, and CYP3A4 enzymes in the body [9].

Because of this, kratom and quercetin’s metabolization and elimination may be slowed, leading them to last for a longer time in the body and causing more side effects.

Kratom & Flavonoids Interactions

Quercetin is a flavonoid that is also a polyphenolic substance. It is most typically used to treat heart and blood vessel problems and prevent cancer. It also helps with diabetes, arthritis, and bladder infections.

Flavonoids have anti-inflammatory properties and protect cells from oxidative damage, resulting in disease. With these dietary antioxidants, cardiovascular disease, diabetes, cancer, and cognitive illnesses like Alzheimer’s and dementia can all be prevented.

There are a few other flavonoids, all of which will share a similar level of risk when used alongside kratom.

Other flavonoids that kratom will interact with include:

  • Apigenin
  • Baicalein
  • Biochanin A
  • Chrysin
  • Daidzein
  • Eriodictyol
  • Formononetin
  • Genistein
  • Glycitein
  • Hesperetin
  • Isorhamnetin
  • Kaempferol
  • Luteolin
  • Myricetin
  • Naringenin

Is it Safe to Take Kratom With Quercetin (Quercetin Bromelain)?

Kratom can raise blood pressure, counteracting the antihypertensive effects of quercetin. This is extremely likely while taking high doses of both drugs for a long time.

Besides this, a metabolic interaction between the two drugs could delay the metabolization of the two drugs, making them last longer in the body and causing side effects that could turn dangerous. It can include side effects like a rise in blood pressure, renal failure, etc. 

As a result, consult your prescribing physician before using these medications. You should never start them on your own. Also, if you encounter any unusual side effects, contact your doctor immediately.

Quercetin Details & Specifications:

Drug Name  Quercetin
Trade nameDoctor’s Best Best Quercetin with Bromelain, Natural Factors Bioactive Quercetin, Bluebonnet Super Quercetin, NOW Foods Quercetin, Thorne Research Quercenase, MoxyVites Quercetin, Sandhu’s Zinc Quercetin
ClassificationFlavonoid
CYP MetabolismNot known. However, it does inhibit CYP2D6, CYP2C19, and CYP3A4  
Interaction With KratomAntagonistic and metabolic
Risk of InteractionMild to Moderate

What is Quercetin (Quercetin Bromelain)?

Quercetin is a flavonoid compound that is also called a polyphenolic compound. Kale, onions, berries, apples, red grapes, broccoli, cherries, tea, and red wine are some of the foods rich in quercetin. 

Quercetin helps prevent diseases like osteoporosis, cancer, tumors, and lung and cardiovascular problems. Quercetin’s antioxidant properties are important in preventing and treating such disorders.

Quercetin may also demonstrate considerable antioxidant activity after creating a complex or combining to generate specific unique formulations employed in human health care, owing to its high solubility and bioavailability.

What is Quercetin (Quercetin Bromelain) Used For?

Quercetin is used for several indications. Some of these are:

As An Antioxidant

Quercetin works as an antioxidant [1]. Quercetin’s antioxidant action is primarily demonstrated by its effects on glutathione (GSH), enzymatic activity, signal transduction pathways, and reactive oxygen species (ROS) produced by environmental and toxicological stimuli.

By maintaining oxidative balance, quercetin has a considerable antioxidant action and acts by regulating the levels of GSH in the body and increasing its amount.

GSH is a substance required by the body to convert harmful H2O2 into non-toxic H2O. Thus, quercetin contributes to protecting the body against harmful antioxidants.

As An Anti-inflammatory Medication

Quercetin also possesses anti-inflammatory properties. In human cells, quercetin lowered inflammatory markers such as tumor necrosis factor-alpha (TNF) and interleukin-6 (IL-6) [2].

Quercetin can also help counteract symptoms of conditions such as rheumatoid arthritis. An 8-week study of 50 women with rheumatoid arthritis found that taking 500 mg of quercetin reduced early morning stiffness, morning discomfort, and after-activity pain considerably [3].

As a Treatment for Allergies

The anti-inflammatory effects of quercetin may help with allergy symptoms. It appears to disrupt enzymes involved in inflammation and reduce inflammation-promoting substances like histamine [4].

Quercetin is known for its anti-allergic qualities, including immune system activation, antiviral activity, inhibition of histamine release, reduction of pro-inflammatory cytokines, leukotriene generation, and suppression of interleukin IL-4 production. It can improve Th1/Th2 balance and prevent the production of antigen-specific IgE antibodies.

It also works to inhibit enzymes, including lipoxygenase, eosinophil, and peroxidase, as well as reduce inflammatory mediators. These abilities help quercetin’s anti-inflammatory and immunomodulating effects, which can treat late-phase and late-late-phase bronchial asthma responses, allergic rhinitis, and restricted peanut-induced anaphylaxis reactions.

As a Treatment for Cancer

Quercetin also possesses anti-cancer properties.

Quercetin can inhibit prostate cancer via various mechanisms [5]. It can induce the death of cancer cells in prostate cancer and has been shown to have a chemopreventive effect on cancer cells.

Slow Down Degenerative Neurological Conditions

Quercetin may have neuroprotective effects and slow down conditions such as Alzheimer’s [6].

Quercetin, a naturally occurring polyphenol, has garnered the most attention as a nutraceutical with neuroprotective properties in the developing, adult, and aging neurological systems. Quercetin demonstrates neuroprotective effects in numerous models of neuronal damage and neurodegenerative disorders and against neurotoxic compounds.

Quercetin’s neuroprotective effects might be because of its ability to induce Nrf2-ARE and induction of the antioxidant/anti-inflammatory enzyme paraoxonase 2 (PON2) are two such mechanisms. Quercetin has also been demonstrated to activate sirtuins (SIRT1), encourage autophagy, and act as a phytoestrogen. All of these processes aid in neuroprotection.

Reduce Blood Pressure

According to research, quercetin may help lower blood pressure [7] and appears to have a relaxing effect on blood arteries. The vasodilator effects of quercetin and its metabolites were selective for resistant arteries.

Similarly, consuming more than 500 mg of quercetin in supplement form daily lowered systolic and diastolic blood pressure according to an analysis of 9 human trials involving 580 persons [8].

What’s the Dose of Quercetin (Quercetin Bromelain)?

The recommended dose of quercetin is 400-500 mg orally three times per day or as recommended by the physician.

Generic & Brand Name Versions

  • Doctor’s Best Best Quercetin with Bromelain
  • Natural Factors Bioactive Quercetin
  • Bluebonnet Super Quercetin
  • NOW Foods Quercetin
  • Thorne Research Quercenase
  • MoxyVites Quercetin
  • Sandhu’s Zinc Quercetin

What Are the Side Effects of Quercetin (Quercetin Bromelain)?

  • Dyspnea
  • Headache
  • Hypersensitivity
  • Nephrotoxicity
  • Paresthesia

Pregnant women, breastfeeding women, and people with renal failure and kidney diseases should avoid quercetin.

What is Kratom?

Kratom comes from the leaves of a Southeast Asian evergreen tree (Mitragyna speciosa). Powdered kratom can be used in many ways, though kratom leaves are traditionally chewed.

Kratom acts like an opioid, though it also affects other systems, giving it many benefits. It functions as a stimulant in low doses, making users feel more energized. It decreases pain and serves as a sedative at high doses.

Some people use kratom to avoid opioid withdrawal symptoms; it is also more readily available and safer than prescription medicines.

However, it can cause addiction and withdrawal symptoms if taken for a long time.

What’s Kratom Used For?

What is the Dose of Kratom?

There is no set dose, but there are averages. To know where to start, figure out the effects you’re after. Remember, low doses are stimulating and best for mood, while larger amounts are for pain and insomnia.

Kratom dosage guidelines:

  • Low doses — 2-5 g
  • Medium doses — 6-8 g
  • Large doses — 9-12 g

What Are the Side Effects of Kratom?

Kratom is safe, but there are side effects to be aware of. However, these are more common with higher doses. If they become an issue, try using less.

  • Abnormal heart rhythms
  • Anxiety
  • Constipation
  • Drowsiness
  • Dry mouth
  • Frequent urination
  • Irritability
  • Itching
  • Liver failure
  • Loss of appetite
  • Nausea
  • Vomiting
  • Withdrawal symptoms with long term use

Take breaks from kratom every week and use the smallest amount possible to avoid addiction.

What Are the Different Types of Kratom?

Another factor in kratom’s effects is the strain used. While all kratom has the same overall effects, each strain has its “specialty.”

A) White Vein Kratom

White veined leaves are picked before they reach full maturity. These strains are well-known for their stimulating properties and can help provide better cognitive performance, improve mental concentration, give an energy boost, and provide an elevated, mildly pleasant sensation. It has effects that are comparable to caffeine.

B) Red Vein Kratom

Before a kratom leaf may produce red veins, it must be fully ripe. The alkaloid profile in red-veined kratom gives these strains potent analgesic and anxiolytic effects.

These provide sedative effects and offer maximum relaxation. Their soothing properties make them great at the end of a long day.

C) Green Vein Kratom

Green vein kratom comes from medium-mature leaves. The veins had achieved a point where all the positive qualities were at their highest. Green vein kratom is often preferable to white or red vein kratom because the effects are subtle but persistent.

These are energizing and uplifting and help keep a person calm with increased concentration levels.

E) Yellow Vein Kratom

Yellow vein kratom is a product of a distinct drying procedure, and it is a type of green vein kratom that’s alkaloid content and effects are altered during this drying phase.

It promotes sensations of pleasure and vitality while also reducing anxiety and malaise. It lasts a surprising amount of time and delivers pain alleviation, increased concentration, and a better overall mood.

Key Takeaways: Is it Safe to Mix Kratom & Quercetin (Quercetin Bromelain)?

There may be a moderate level of interaction between kratom and quercetin. Quercetin lowers blood pressure while kratom raises it at high dosages; hence their interaction is considered antagonistic. As a result, combining them could counteract each other’s effects.

Never start taking these medications without first consulting your prescribing physician.

References

  1. Xu, D., Hu, M. J., Wang, Y. Q., & Cui, Y. L. (2019). Antioxidant activities of quercetin and its complexes for medicinal application. Molecules, 24(6), 1123.
  2. Chuang, C. C., Martinez, K., Xie, G., Kennedy, A., Bumrungpert, A., Overman, A., … & McIntosh, M. K. (2010). Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-α–mediated inflammation and insulin resistance in primary human adipocytes. The American journal of clinical nutrition, 92(6), 1511-1521.
  3. Javadi, F., Ahmadzadeh, A., Eghtesadi, S., Aryaeian, N., Zabihiyeganeh, M., Rahimi Foroushani, A., & Jazayeri, S. (2017). The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: a double-blind, randomized controlled trial. Journal of the American College of Nutrition, 36(1), 9-15.
  4. Mlcek, J., Jurikova, T., Skrovankova, S., & Sochor, J. (2016). Quercetin and its anti-allergic immune response. Molecules, 21(5), 623.
  5. Yang, F., Song, L., Wang, H., Wang, J., Xu, Z., & Xing, N. (2015). Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential. Oncology reports, 33(6), 2659-2668. x
  6. Costa, L. G., Garrick, J. M., Roquè, P. J., & Pellacani, C. (2016). Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxidative medicine and cellular longevity, 2016.
  7. Pérez-Vizcaı́no, F., Ibarra, M., Cogolludo, A. L., Duarte, J., Zaragozá-Arnáez, F., Moreno, L., … & Tamargo, J. (2002). Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. Journal of Pharmacology and Experimental Therapeutics, 302(1), 66-72.
  8. Serban, M. C., Sahebkar, A., Zanchetti, A., Mikhailidis, D. P., Howard, G., Antal, D., … & Lipid and Blood Pressure Meta‐analysis Collaboration (LBPMC) Group. (2016). Effects of quercetin on blood pressure: a systematic review and meta‐analysis of randomized controlled trials. Journal of the American Heart Association, 5(7), e002713.
  9. Chen, Y., Xiao, P., Ou‐Yang, D. S., Fan, L., Guo, D., Wang, Y. N., … & Zhou, H. H. (2009). Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N‐acetyltransferase, and xanthine oxidase activity in healthy volunteers. Clinical and Experimental Pharmacology and Physiology, 36(8), 828-833.

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