Kratom Guides

What Happens if You Mix Kratom & Orange Juice?

Mixing orange juice and kratom (Mitragyna speciosa) is one of the best ways to hide kratom’s bitter taste.

Orange juice also acts as a potentiator, though, so you need to be aware of how much you’re ingesting. As part of the potentiating effects, mixing kratom with orange juice brings a heightened risk of side effects from kratom. 

Most people mix about 2-4 grams of powder for every set of four freshly squeezed oranges.

Last updated 10 months ago by Wade Paul

What Happens if You Mix Kratom & Orange Juice?

Does Kratom Interact With Orange Juice?

Kratom doesn’t significantly interact with orange juice. However, mild potentiation may occur, leading to a slightly higher risk of side effects.   

Kratom requires two specific enzymes in the liver — CYP2D6 and CYP3A4 [1]. Although orange juice does increase the metabolic ratio of CYP3A4 by approximately 7 percent, this isn’t enough to have a substantial impact on other substances that use CYP3A4 [2]. 

However, if you choose Seville orange juice specifically, the inhibition of CYP3A4 will be much more significant.

Some other citrus fruits do present a more significant problem, though, especially grapefruit juice

Is It Safe to Take Kratom With Orange Juice?

It’s generally regarded as safe to take kratom with orange juice.

In fact, orange juice is the most common beverage people use to mask the taste of kratom.  

Unlike grapefruit juice, your morning glass of OJ doesn’t have much of an impact on kratom. 

Orange juice has high amounts of antioxidants and vitamins and a strong citrus flavor. It can also extract and dissolve a larger number of alkaloids than most beverages. This allows it to be a nearly perfect mask for the off-putting taste of kratom powder. 

Be aware that anything that potentiates kratom carries some risks

Orange juice may be one of the lowest risk items, but there is still a chance that it could cause problems. This becomes especially noteworthy if you take it every day.   

The most likely adverse effect from this interaction is a higher chance of side effects from kratom — such as nausea, headaches, dizziness, or fatigue. Severe side effects are very unlikely. 

Orange juice and droplets isolated on white background. 3D illustration

What is Kratom?

The kratom tree hails from Southeast Asia. It’s part of the coffee family and has been used for medicinal purposes since at least the 19th century. 

Kratom has gained a reputation for helping people with opioid withdrawal. It can have stimulating or sedating effects, depending on how much you take. 

The most common uses for kratom are to help manage chronic pain, alleviate anxiety, improve sleep onset, elevate mood, improve focus and concentration, and as an energy-booster

What’s The Dose of Kratom?

Kratom newcomers would be well-served by sticking with two grams or less for the first dose. Only once you’re familiar with how your body reacts to kratom should you move on to a larger dose. 

General dosage guidelines for kratom include: 

  • Low-Dose Kratom (2–6 grams of dried powder)
  • High-Dose Kratom (6–12 grams of dried powder)

The more kratom you take, the more likely you are to have problems with it. As long as you don’t exceed 12 grams, though, you will most likely be fine. 

Anyone who exceeds 12 grams has a slightly higher risk of becoming addicted and/or going through withdrawal once they stop using kratom. 

What are the Side Effects of Kratom?

Kratom doesn’t tend to cause a lot of side effects. In fact, it’s generally well-tolerated, especially in a lower dose. If you do deal with side effects, however, they are likely to be one (or more) of the following.  

Common side effects of kratom include: 

  • Nausea
  • Vomiting 
  • Anxiety
  • Brain fog 
  • Cognitive impairment 
  • Sedation 
  • Lethargy 
  • Constipation 
  • Dizziness 

What are the Different Types of Kratom?

Kratom has many strains, which are divided into four different classes: white, red, green, and yellow. 

Within each class are dozens of different strains. Each strain offers its own specific qualities, although they usually match their class. 

Here’s a quick run-down of the different kratom strain classes

  1. White Vein Kratom — Best for concentration, energy, and focus. Effects are euphoric and energizing. 
  2. Red Vein Kratom — Best for pain and sleep, powerful and fast-acting. Effects are numbing and relaxing. 
  3. Green Vein Kratom — Balanced between white and red (sedating and stimulating).
  4. Yellow Vein Kratom — Made from a combination of white kratom and other strains. Effects cover all ranges of the spectrum (sedating or stimulating). 
Mitragyna speciosa korth wrapper for eating isolated from white background. leaves of Mitragyna speciosa (Kratom).

Key Takeaways: Is it Safe to Mix Kratom & Orange Juice?

Orange juice and kratom are relatively safe to mix together. However, that doesn’t mean this combination isn’t without risk. 

Some of the compounds in orange juice act as a potentiator (makes kratom stronger). This could mean that taking kratom and orange juice together can lead to a higher chance of side effects from the kratom. 


  1. Kamble, S. H., Sharma, A., King, T. I., León, F., McCurdy, C. R., & Avery, B. A. (2019). Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica, 49(11), 1279-1288.
  2. Niewiñski, Przemys³aw & Jaÿwiñska-Tarnawska, Ewa & Orzechowska-Juzwenko, Krystyna & Czarnik-Matusewicz, Henryk & Hurkacz, Magdalena & Niewiñska, Kinga & Wiela-Hojeñska, Anna. (2007). Orange juice has no effect on CYP2D6-dependent drug metabolism. Pharmacological Reports. 59.