Drug Interactions, Kratom Guides

What’s the Deal With Kratom & Piracetam?

Piracetam is a nootropic with certain medical applications.

Kratom is a herbal compound with opioid-like properties and a stunning array of benefits.

These two compounds are quite distinct, but at the same time, they are in similar situations. Both drugs are currently under a fair amount of controversy as members of the scientific and medical community sternly disagree on their uses and benefits.

In piracetam’s case, it’s still too early to make definitive statements. Kratom is a little different considering the lack of research, and the government seems determined to smear it without looking at the results we do have.

Last updated 4 months ago by Dr. Devin Carlson

What’s the Deal With Kratom & Piracetam?

Does Kratom Interact With Piracetam?

Kratom and piracetam do not seem to interact with each other. Both share nootropic benefits, but they don’t have an agonistic relationship or act as metabolic competitors.

Agonistic relationships are common in pharmacological drugs that have similar mechanisms of action. For instance, mixing kratom with morphine is dangerous since both compounds target opioid receptors in the central nervous system. Agonistic relationships tend to increase the incidence of adverse effects.

However, this effect is far less pronounced when it comes to nootropic drugs.

In terms of their effects, piracetam and kratom do not interact meaningfully with each other.

When it comes to their metabolic process, kratom and piracetam also have no interaction. From what we know so far, piracetam does not have any major process of metabolism — 80-100% of the drug is excreted unchanged through the urine.

Piracetam does not induce or inhibit kratom’s metabolism, and they are not metabolic competitors.

Is it Safe to Take Kratom With Piracetam?

Yes. It should be safe to take kratom and piracetam together.

However, these compounds have not been extensively studied, and both still have individual side effects that you always have to consider.

The best strategy for avoiding severe adverse effects is to only consume these drugs in small to mid-size doses and avoid taking them simultaneously. Check with your doctor for more guidance.

What is Piracetam?

Piracetam has purported nootropic benefits and some limited medical applications.

Piracetam is sold as a medication in certain European countries but has not received any FDA approval for medical indications in the United States. Although the FDA does not regulate it, it is legal to buy piracetam in the US.

Piracetam is in the racetams class of drugs. Some drugs in this category are considered nootropics. More specifically, piracetam is a cyclic derivative of the GABA neurotransmitter.

Piracetam Specs

Drug NamePiracetam
Trade NameDinagen
ClassificationRacetams
CYP MetabolismNot CYP mediated
Interaction With KratomNone
Risk of InteractionLow

What is Piracetam Used for?

The medical evidence for piracetam’s usefulness is contradictory in many cases, but there are some promising results.

As a nootropic, there is a solid body of research indicating that piracetam can improve mental function in cognitive processes such as learning and memory [1]. Evidence suggests that piracetam has antithrombotic, neuroprotective, and rheological benefits [2].

Some research also claims that piracetam is effective at helping patients with dementia or cognitive problems. However, a study done by Cochrane concluded that there is not enough evidence to support this conclusion [3].

There’s also evidence supporting piracetam’s ability to treat certain aspects of other ailments such as cardiovascular disease, vasoconstriction, vertigo [4], and depression [5].

Generic & Brand Name Versions

Piracetam can be found under the following brand names:

  • Dinagen
  • Myocalm
  • Nootropil
  • Qropi

What’s the Dose of Piracetam?

The proper dosage of piracetam will vary based on the ailment being treated.

The recommended dosage for piracetam is as follows [6]:

Adults:

  • For surgery to improve blood flow to the heart (CABG surgery): Piracetam 12 grams daily for six weeks, starting on day six after surgery.
  • For seizure disorder (epilepsy): Piracetam 9.6-24 grams daily for up to 18 months.
  • For a movement disorder often caused by antipsychotic drugs (tardive dyskinesia): Piracetam 2.4 grams twice daily for four weeks.
  • For vertigo: Piracetam 800 mg three times daily for 1-8 weeks.

Children:

  • For breath-holding attacks: Piracetam 40 mg/kg daily for 2-3 months in children 6-36 months.
  • For dyslexia: Piracetam 3.3 grams daily for at least 12 weeks in children aged 7-14 years.

What Are the Side Effects of Piracetam?

Taking piracetam can cause the following adverse effects [7]:

  • Agitation
  • Anxiety
  • Clinical depression
  • Headache
  • Hyperkinesia
  • Increased libido
  • Insomnia
  • Irritability
  • Nervousness
  • Somnolence
  • Tremor
  • Weakness
  • Weight gain

Additionally, it is common for users to report no apparent improvement in cognitive function after taking piracetam.

What is Kratom?

Mitragyna speciosa — commonly known as kratom — is a psychoactive plant with many beneficial properties. It grows plentifully in Southeast Asia, where it’s been a staple in traditional medicine.

It derives its benefits from the plant-based alkaloids contained within it. Alkaloids are a class of naturally-occurring compounds that often have pharmacological effects. Two in particular play a huge role in kratom’s effects: mitragynine and 7-hydroxymitragynine.

It took a while to catch on, but now kratom is quite popular in the United States and the rest of the western world; however, there’s still a lot of doubt about what it is and what it can do.

Unfortunately, the FDA is targeting kratom for legislation. Nevertheless, the kratom community in the United States is strong. It’s even backed by influential organizations like the American Kratom Association, which helps fight for kratom to remain legal.

What is Kratom Used for?

Kratom has a vast spectrum of uses.

When consumed in low doses, kratom acts as a stimulant and can produce powerful cognitive benefits, just like coffee and the coca leaf!

Small amounts provide feelings of euphoria and promote mental and physical energy.

However, the larger the amount, the more the effects change. It goes from stimulating to sedating, but bigger doses also provide potent analgesic and anti-anxiety benefits.

To summarize, kratom can help with the following, but the effects depend on how much you take:

What’s the Dose of Kratom?

You’ll have to experiment a little to find what’s right for you, but it’s always best to start low and work your way up; no sense in taking more than you need. Still, it’s good to have a general idea of what’s considered a low or high amount.

Here are the generalized kratom dosages:

  1. Low dose (1–5 g): this range best promotes kratom’s stimulant, mind-based effects.
  2. Medium dose (5–10 g): analgesic and anxiolytic properties become more evident.
  3. High dose (10–12 g): heavy doses are best for sedative, analgesic, and anxiolytic effects. Do not consume this amount of kratom if you’re unsure as to how your body will handle it.

As you can see, it’s quite essential to have a solid grasp of the amount of dosing if you want to control what effects you feel.

Remember to be mindful of how your body reacts to kratom; you might be sensitive to it.

What Are the Side Effects of Kratom?

Kratom, like all drugs, has its fair share of side effects:

The following are far less common but something to watch out for — these generally mean you took too much or need a long break.

  • Low blood pressure
  • Low libido
  • Poor appetite
  • Seizures
  • Tremors

Kratom can also cause mental and physical dependence.

Kratom addiction is less likely when compared to pharmacological drugs like antidepressants or painkillers, but it’s always a possibility.

Make sure to become familiar with the dangers of kratom use.

Kratom leaf and flower.

What Are the Different Types of Kratom?

Kratom comes in many different strains.

So what does this mean for you? You get variety and a chance to meet many needs with one special plant. Essentially, all of kratom’s strains share basic properties. However, the alkaloid content in these strains means each one acts a little differently. Some tend to be better for pain but will make you tired, while others will get you moving but don’t offer as much pain relief.

These variations in kratom strains mean it’s vital you have a basic idea of what each one does. Otherwise, you might end up lethargic when you need to get through the last few hours of work.

A) White Vein Kratom

If you are someone who’s looking to replace their morning dose of coffee with something a little more energetic — try white vein kratom.

These strains are associated with the stimulating, nootropic benefits you can generally produce with a low dose.

B) Red Vein Kratom

Red vein kratom is extremely popular with those suffering from chronic pain or anxiety. This is because red-veined kratom strains are known to be relaxing and more potent pain-relievers.

C) Green Vein Kratom

Green vein kratom exists in the middle of the kratom spectrum. This particular strain doesn’t emphasize the specific benefits of kratom; it promotes all of them. If you don’t need substantial pain relief or energy, green strains are usually the way to go.

D) Yellow Vein Kratom

Yellow vein kratom is probably the least remarkable out of all the kratom strains — tough, we know.

The yellow veins have no distinguishing features except that it is the mildest out of all the strains. Besides that, users often report it’s similar to green vein kratom.

Yellow vein kratom is popular with first-timers and those who are sensitive to kratom.

Key Takeaways: Is it Safe to Mix Kratom & ​​Piracetam?

In conclusion, there is no reason to be afraid of mixing kratom and piracetam, but it requires care and awareness. There’s little information on both, so be careful.

Our only concern is that since piracetam is unregulated in many countries, most people will attempt to self-administer it, which could lead to inaccurate dosing.

If you’re determined to use piracetam as a nootropic or for medical applications, try to consult a doctor before starting it. If you cannot, use careful research to determine the proper dosage for your specific treatment goals.

References

  1. Vernon, M. W., & Sorkin, E. M. (1991). Piracetam. Drugs & Aging, 1(1), 17-35.
  2. Winnicka, K., Tomasiak, M., & Bielawska, A. (2005). Piracetam-an old drug with novel properties. Acta Pol Pharm, 62(5), 405-409.
  3. Flicker, L., & Evans, J. G. (2004). Piracetam for dementia or cognitive impairment. Cochrane Database of Systematic Reviews, (1).
  4. Malykh, A. G., & Sadaie, M. R. (2010). Piracetam and piracetam-like drugs. Drugs, 70(3), 287-312.
  5. Winblad, B. (2005). Piracetam: a review of pharmacological properties and clinical uses. CNS drug reviews, 11(2), 169-182.
  6. De Reuck, J., & Van Vleymen, B. (1999). The clinical safety of high-dose piracetam-its use in the treatment of acute stroke. Pharmacopsychiatry, 32(S 1), 33-37.
  7. Chouinard, G., Annable, L., Ross-Chouinard, A., Olivier, M., & Fontaine, F. (1983). Piracetam in elderly psychiatric patients with mild diffuse cerebral impairment. Psychopharmacology, 81(2), 100-106.

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