Does Kratom Interact With Trazodone?
Trazodone can interact with kratom agonistically and metabolically. This can cause an increased risk of side effects, including sedation, headaches, nausea, and serotonin syndrome. The interaction is considered moderate to high.
It’s always best to talk to your doctor before combining kratom and trazodone.
There is an agonistic interaction between kratom and trazodone.
Agonistic interaction occurs when two substances having the same effect are used together. These substances produce a similar effect by acting on the same receptors or acting on different receptors that cause similar responses.
Kratom acts as a stimulant in lower doses, but it can cause sedation in higher doses. It primarily works on mu-opioid receptors, resulting in pain relief . Kratom also affects D2 dopamine and serotonin (5-HT2c and 5-HT7) receptors, with potential antipsychotic and antidepressant effects .
Trazodone acts via antagonism of serotonin receptors and inhibition of serotonin transporters. The drug has an antidepressant effect and sleep-inducing properties .
Due to their similar effects, kratom and trazodone can cause marked sedation and even respiratory depression. As both drugs affect serotonin, using them together can lead to a severe side effect known as serotonin syndrome . Serotonin syndrome is characterized by restlessness, confusion, and loss of muscle coordination.
All oral drugs need to be metabolized once consumed. The liver produces enzymes that mediate drug metabolism. Using two drugs metabolized by common enzymes results in a slower breakdown of both drugs.
Trazodone is mainly metabolized by the liver enzyme CYP3A4 . Kratom is also metabolized by CYP3A4. The two drugs may compete for metabolism, resulting in an increased duration of effect of both substances.
Trazodone is an antidepressant and, when consumed daily, can accumulate in the blood up to toxic levels, mainly when used with kratom.
Trazodone is a serotonin receptor and reuptake inhibitor. This class of drugs treats major depressive disorders. In addition, these drugs are used in post-traumatic stress disorder and sleep disorders.
Other SARIs and kratom have a similar level of risk.
Other serotonin receptor agonists and reuptake inhibitors that kratom will interact with include:
- Etoperidone (Axiomin, Etonin)
- Lorpiparazole (Normarex)
- Mepiprzole (Psigodal)
- Nefazodone (Serzone, Nefadar)
No. It is not safe to take kratom with trazodone.
Kratom and trazodone’s interaction is considered moderate to severe.
Kratom in high dosage can increase the sleep-inducing effect of trazodone. This can lead to severe drowsiness even after the intended duration of action of the drugs. In addition, serotonin syndrome is a dangerous side effect of both drugs.
Consult your prescribing physician before the use of these drugs. If you notice any side effects, seek help from a medical professional.
Trazodone is a serotonin receptor antagonist and reuptake inhibitor. It is a triazolopyridine derivative.
Trazodone inhibits serotonin transporter and blocks the reuptake of serotonin, which results in improved mood. The drug also shows antagonism in 5-HT2A and 5-HT2c serotonin receptors. The drug also blocks histamine and alpha-1-adrenergic receptors.
The drug helps manage major depressive disorder. It is also valuable for generalized anxiety disorder, post-traumatic stress disorder, and insomnia.
Trazodone Details & Specifications:
|Trade name||Azona, Cirzodone, Codipzona, Deprax, Depryl, Desyrel, Diapresan, Donaren, Mesyrel, Molipaxin, Nestrolan, Reslin, Sideril, Tazodac, Torlex, Trarett, Trazalon, Trazo, Trazodona, Trazolan, Trazone, Trazonil, Triticum, Tronsalan|
|Classification||Serotonin antagonists and reuptake inhibitors, Antidepressant|
|Interaction With Kratom||Agonistic|
|Risk of Interaction||Moderate to high|
Trazodone is primarily used for the treatment of depression. The uses of trazodone are:
Trazodone is used for the treatment of depression with or without anxiety. It is used due to its minimal anticholinergic activity but can also augment the antidepressant effect of other antidepressants. Due to its sedative effect, it is very effective in geriatric patients who have depression with insomnia.
Trazodone helps with post-traumatic stress disorder, panic disorder, generalized anxiety disorder, and obsessive-compulsive disorder. The sleep-inducing property helps reduce sleep disturbances and nightmares in post-traumatic stress disorder.
Treatment of insomnia is one of the off-label uses of trazodone. It is used in low doses as a sleeping aid.
The recommended initial dose of trazodone is 75 to 150 mg orally per day. Doctors adjust the amount according to the needs of the patient.
- Blurred vision
- Dry mouth
- In coordination
Because of its wide array of effects, some governments have banned it. However, the World Health Organization studied kratom and determined it is safe. This backs up hundreds of years of use and anecdotal reports — as does the available research.
Those native to Southeast Asia, where kratom grows plentifully, have used this plant as traditional medicine for a long time. The rest of the world is now catching on to its vast uses. Here are the top reasons people use kratom — sometimes even replacing their prescriptions.
The dose depends on the effects you’re looking for. Start with a low amount to see how it affects you.
- Pain, anxiety, and sleep: Larger doses, usually 6-12 g
- Energy, focus, and mood: Smaller doses, usually 2-5 g
Kratom doesn’t affect everyone the same way, and many factors come into play. The kratom dosage guide can help narrow down the right dose for the job.
Kratom gets its fair share of negative press, but that’s about all it amounts to. The reality is there’s little risk to using kratom as long as it’s used responsibly. That means not combining it with other substances, using it only when necessary, and taking breaks from it.
There are some side effects to be aware of — including addiction — though they tend to be mild and short-lived.
Kratom’s effects also depend on the strain. When buying kratom, pay attention to the strain so you aren’t surprised. Here’s a look at each strain color and their common effects.
The green vein kratom falls in the middle of the red and white strains. These offer a pleasant balance; they’re neither too stimulating nor too relaxing — although the effects are prominent depending on the dose.
Kratom and trazodone can have a moderate to high level of interaction. Their interaction is agonistic, though they are also metabolic competitors. Both trazodone and high doses of kratom induce sleep, so taking them together can cause dangerous levels of sedation.
Furthermore, serotonin syndrome is another adverse effect of both drugs, leading to agitation, dilated pupils, loss of muscle coordination, rapid heart rate, and even death if left untreated.
Do not take these medications without consulting your doctor.
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